Preprint Watch

Evolution of Wormholes under f(R, T) Theory, the Karmarkar Condition and the Casimir Energy

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.02074.pdf Stage Model Drift Paradigm framing The preprint operates within the established paradigm of Einstein's General Relativity, specifically focusing on the sub-paradigm of wormhole physics. It also engages with the extended paradigm of modified gravity, represented by f(R,T) theory. Highlights This preprint explores wormhole solutions within the f(R,T) gravity theory, a modification of Einstein's […]

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Exploring the use of Virtual Reality to enhance rapid decompression from occupational stress during short wellness breaks for content moderators

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5684444/v1_covered_6871fded-8bc3-44c1-a101-5f10e11abdc8.pdf Stage Normal Science Paradigm framing Psychology, Occupational Health, Human-Computer Interaction Highlights This preprint investigates the application of Virtual Reality (VR) for stress reduction in a specific occupational group (content moderators). While the study did not demonstrate significant changes in long-term, trait-based anxiety or occupational stress, it did show reductions in short-term, state-based stress

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Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.06.03.657600v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and genetics as applied to understanding and treating Spinal Muscular Atrophy (SMA). This paradigm emphasizes the role of SMN protein deficiency as the central cause of SMA and focuses on therapies that increase SMN levels. Highlights This preprint

Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam. Read More »

Behavioral plasticity and the valence of indirect interactions

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2024.08.15.608151v2.full.pdf Stage Model Drift Paradigm framing The preprint operates within the paradigm of predator-prey interactions and community ecology, specifically focusing on how individual behavior can influence population dynamics and species interactions. Highlights This preprint presents a model refinement of apparent competition by incorporating behavioral plasticity, specifically hiding behavior in prey species. The core paradigm

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When does rebleeding occur in subarachnoid hemorrhage? Revisiting rebleeding cases with a focus on blood pressure

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.23.25328264v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing is the prevention and management of rebleeding in patients with subarachnoid hemorrhage (SAH), a critical condition with high mortality and morbidity rates. The study operates within the existing paradigm of early intervention and blood pressure management in SAH. Highlights This research firmly falls within the

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Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2024.12.02.24318298v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience, specifically focusing on the basal ganglia's role in motor control and its dysfunction in Parkinson's Disease. It adheres to the established framework of electrophysiological investigation of neuronal activity and network oscillations. Highlights This research investigates the role of the

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Cracking the Undruggable: Discovery of a Mutation-Induced Cryptic Pocket in TP53 C238Y for Precision Oncology

Leave a Comment / Model Revolution, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6651642/v1/564bb168-231f-48c3-8fd7-d3cbf5797c65.pdf Stage Model Revolution Paradigm framing The established paradigm of mutant TP53 being "undruggable" due to a lack of stable binding pockets. Highlights This preprint presents compelling computational evidence challenging the current paradigm by demonstrating the existence of a mutation-induced cryptic pocket in the TP53 C238Y mutant. While the in silico findings are robust

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. Highlights The preprint investigates the effects of computational thinking (CT) training on executive functions in fifth-grade children. It falls under normal science because it operates within the established paradigms of cognitive science, educational science, and computer science. The study seeks to

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Generative AI and Organizational Structure in the Knowledge Economy

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.00532.pdf Stage Model Drift Paradigm framing The preprint operates within the knowledge-based hierarchy paradigm of organizational structure, focusing on how expertise is distributed and utilized within firms. It examines the impact of a novel technology, Generative AI (GenAI), on this established paradigm. Highlights This preprint exhibits characteristics of both normal science and model drift.

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Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.30.656906v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular genetics and genomics, specifically focusing on the established understanding of gene mutations, RNA processing, and protein synthesis. It also adheres to the broader paradigm of Mendelian inheritance in explaining disease etiology. Highlights This preprint investigates the functional impact of

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