Model Drift

Preprints revealing inconsistencies, weak fits, or unexplained anomalies in dominant models—early signs of conceptual stress within the current framework.

Modeling the Global Citation Network using the Scalable Agent-based Simulator for Citation Analysis with Recency-emphasized Sampling (SASCA-ReS)

Leave a Comment / Model Drift /

URL https://zenodo.org/records/17789558/files/tbp.pdf Stage Model Drift Paradigm framing The paper operates within the scientometrics paradigm, specifically focusing on the computational modeling of citation network dynamics. This paradigm seeks to explain the large-scale structure and evolution of scientific literature through generative models based on principles like preferential attachment, recency, and fitness. The research puzzle is to create […]

Modeling the Global Citation Network using the Scalable Agent-based Simulator for Citation Analysis with Recency-emphasized Sampling (SASCA-ReS) Read More »

Iron deficiency drives metabolic adaptation of red pulp macrophages via ferroportin-SYK signaling and BCAA catabolism to enhance erythrophagocytosis

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.06.13.659526v3.full.pdf Stage Model Drift Paradigm framing The research is situated within the established paradigms of cellular iron homeostasis, macrophage biology, and efferocytosis. The prevailing model posits that systemic iron levels are controlled by the hepcidin-ferroportin axis and that macrophages undergo specific metabolic reprogramming to clear aged cells. This paper investigates the adaptive response of

Iron deficiency drives metabolic adaptation of red pulp macrophages via ferroportin-SYK signaling and BCAA catabolism to enhance erythrophagocytosis Read More »

What makes a mycoparasite? Similarities between fungi that attack other fungi and fungal and oomycete plant pathogens based on structural homology of their candidate effectors

Leave a Comment / Model Drift, Research Square /

URL https://www.researchsquare.com/article/rs-7759314/v1.pdf Stage Model Drift Paradigm framing The paper operates within the established paradigm of mycology that defines mycoparasitism as a fungal lifestyle. However, it challenges the paradigm's lack of molecular-level explanation by proposing a new conceptual framework: that the molecular machinery of mycoparasitism (specifically effector proteins) is analogous to that of fungal plant pathogenesis.

What makes a mycoparasite? Similarities between fungi that attack other fungi and fungal and oomycete plant pathogens based on structural homology of their candidate effectors Read More »

On the Abundance Discrepancy Problem in H II Regions

Leave a Comment / Model Drift /

URL https://arxiv.org/pdf/0707.3518.pdf Stage Model Drift Paradigm framing The paper operates within the paradigm of determining chemical abundances in photoionized nebulae (H II regions). This field has long faced the "abundance discrepancy problem," an anomaly where abundances from recombination lines (ORLs) are higher than from collisionally excited lines (CELs). Two competing explanations exist: the "temperature fluctuations"

On the Abundance Discrepancy Problem in H II Regions Read More »

Cloud structure and young star distribution in the Dragonfish complex

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2406.18432.pdf Stage Model Drift Paradigm framing The paper operates within the established paradigm of star formation, where stars are born from the turbulent, fractal structures of interstellar gas clouds. This framework predicts that the spatial distribution of young stars should reflect the fractal structure of their parent cloud, allowing for a quantitative comparison using

Cloud structure and young star distribution in the Dragonfish complex Read More »

Predictive Emotional Selfhood in Articial Minds (PESAM): A Unied and Synergistic Variational Framework

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-7713015/v1_covered_edbb151e-5647-4e84-9b22-f21605513872.pdf Stage Model Drift Paradigm framing The preprint operates within the paradigm of the Active Inference framework and the Free Energy Principle in computational neuroscience and artificial intelligence. This paradigm posits that intelligent agents perceive, act, and learn by continuously minimizing prediction error (or surprise) about their sensory inputs. The paper specifically addresses the

Predictive Emotional Selfhood in Articial Minds (PESAM): A Unied and Synergistic Variational Framework Read More »

An Ontology-Based Analysis of Health Disorders Derived from Stress-Evoked Peripheral Immune Responses

Leave a Comment / medRxiv, Model Drift /

URL https://www.medrxiv.org/content/10.1101/2025.09.14.25335729v1.full.pdf Stage Model Drift Paradigm framing The paper operates within the established psychoneuroimmunology paradigm, which posits that chronic stress triggers peripheral immune responses and low-grade inflammation, contributing to the pathogenesis of various diseases. The research addresses the lack of a formal structure for understanding the specific immunological pathways that link stress to a diverse

An Ontology-Based Analysis of Health Disorders Derived from Stress-Evoked Peripheral Immune Responses Read More »

Who is Responsible When AI Fails? Mapping Causes, Entities, and Consequences of AI Privacy and Ethical Incidents

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2504.01029.pdf Stage Model Drift Paradigm framing The dominant paradigm in AI ethics and governance posits that the risks and harms of AI systems can be managed through structured frameworks, principles, and taxonomies that guide policy and practice. This paradigm assumes that by identifying, classifying, and understanding AI failures, practitioners and policymakers can develop effective

Who is Responsible When AI Fails? Mapping Causes, Entities, and Consequences of AI Privacy and Ethical Incidents Read More »

Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination

Leave a Comment / Model Drift /

URL https://blog.fdik.org/2025-07/preprints202507_2155_v1.pdf Stage Model Drift Paradigm framing The preprint operates within the dominant paradigm of molecular biology and immunology, specifically focusing on transcriptomics and immune responses related to mRNA vaccines. Highlights This preprint presents findings that challenge certain aspects of the current understanding of mRNA vaccine safety, potentially indicating a model drift. While not proposing

Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination Read More »

Who is Responsible When AI Fails? Mapping Causes, Entities, and Consequences of AI Privacy and Ethical Incidents

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2504.01029.pdf Stage Model Drift Paradigm framing Socio-Technical, Governance, and Human-Computer Interaction Highlights This preprint analyzes real-world incidents related to AI systems through the lens of Thomas Kuhn's paradigm cycle. While it doesn't propose a radical shift in our understanding of AI (a paradigm shift), it does highlight significant discrepancies between existing theoretical frameworks and

Who is Responsible When AI Fails? Mapping Causes, Entities, and Consequences of AI Privacy and Ethical Incidents Read More »