Preprint Watch

Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2024.12.24.24319598v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the paradigm of normative modeling in neuroimaging, which seeks to understand brain structure and function relative to established norms. Highlights This preprint presents a refinement (N³) of existing normative modeling techniques, aiming to address limitations in handling heterogeneity within study populations.

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Draft genome and transcriptomic sequence data of three invasive insect species

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.12.02.626401v3.full.pdf Stage Normal Science Paradigm framing Genomics and Bioinformatics Highlights This preprint presents genomic and transcriptomic data for three invasive insect species. It falls under the "normal science" stage of Kuhn's paradigm cycle. The research operates within the established paradigms of genomics and bioinformatics, utilizing accepted methods like whole-genome sequencing, RNA-seq, and Hi-C sequencing.

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Fuzzy Recurrence Dynamics of Contrast Medium Extravasation in Computed Tomography

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URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323651v1.full.pdf Stage Normal Science / Model Drift Paradigm framing Established paradigm of computed tomography (CT) imaging analysis in trauma care. Highlights This preprint resides primarily within the normal science stage of Kuhn’s paradigm cycle. It operates within the established paradigm of CT imaging for trauma assessment but introduces a novel analytical approach (fuzzy recurrence

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Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.08.29.610326v4.full.pdf Stage Normal Science Paradigm framing The current paradigm in auditory research is the power spectrum model of masking. The dominant theory is that behavioral frequency selectivity measurements should roughly correspond to cochlear frequency tuning, at least at lower sound levels. This assumes that the behavioral responses are largely driven by cochlear processes. Highlights

Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist Read More »

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions

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URL https://www.biorxiv.org/content/10.1101/2024.06.28.601145v2.full.pdf Stage Normal Science Paradigm framing Current neurovascular coupling (NVC) and brain imaging paradigms Highlights The study uses established NVC concepts and advanced imaging techniques to investigate the role of astrocytes in NVC within the existing paradigm. There is no significant challenge to current paradigms but the study may inspire further studies. The research

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions Read More »

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.15.654070v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of oxygen sensing in vertebrates, which involves specialized respiratory chemoreceptors. This paradigm includes the established role of acetylcholine (ACh) in oxygen sensing in the mammalian carotid body and pulmonary neuroepithelial bodies (NEBs), as well as the recognized presence and role of serotonin

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Stimulant medications affect arousal and reward, not attention

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654915v2.full.pdf Stage Model Drift Paradigm framing The dominant paradigm is the attention-network model of stimulant action. This model suggests that stimulants primarily improve attention by directly modulating attention networks in the brain. Highlights This preprint challenges the prevailing paradigm by presenting evidence suggesting that the primary effect of stimulants is on arousal and reward

Stimulant medications affect arousal and reward, not attention Read More »

Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma

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URL https://www.biorxiv.org/content/10.1101/2025.05.16.654440v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the established use of chemotherapy, radiotherapy, and surgery for Ewing sarcoma. Highlights This preprint presents research on oncolytic Maraba virus MG1 as a potential treatment for Ewing sarcoma. The research is conducted within the framework of existing cancer treatment paradigms, exploring a new therapeutic

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A Collaborative Approach to Improving Missense Mutational Effect Predictions in Oncoproteins

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URL https://www.medrxiv.org/content/10.1101/2025.05.15.25327738v1.full.pdf Stage Normal Science Paradigm framing The current paradigm for predicting the effects of missense mutations relies on a variety of computational tools, each with its own strengths and weaknesses. This paper operates within this established paradigm but seeks to refine it. Highlights This preprint presents the "APE score," a novel ensemble metric that

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Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.15.654311v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and proteomics, specifically focusing on the identification and quantification of proteins in blood as a means to understand physiological and pathological states. Highlights This research represents a significant contribution to normal science within the field of blood proteomics.

Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body Read More »