Preprint Watch

Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654176v1.full.pdf Stage Model Drift Paradigm framing Nucleic acid quantification using enzyme-free isothermal amplification methods Highlights This preprint presents an attempt to replicate and validate the non-enzymatic isothermal strand displacement and amplification (NISDA) assay, a recently introduced method for nucleic acid detection. The authors’ inability to reproduce the sensitivity levels reported in the original NISDA

Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification Read More »

Herbaria provide a valuable resource for obtaining informative mRNA

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.02.12.637878v1.full.pdf Stage Normal Science Paradigm framing Transcriptomics and Molecular Biology Highlights This preprint investigates the utility of herbarium specimens for mRNA transcriptomics, a field traditionally reliant on DNA. While acknowledging the established paradigm of RNA instability, the authors challenge the assumption that herbarium specimens are unsuitable for RNA-based studies. By successfully assembling transcriptomes from

Herbaria provide a valuable resource for obtaining informative mRNA Read More »

Separating the genetics of disease, treatment and treatment response using graphical modeling and large-scale electronic health records

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.04.29.25326633v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of genome-wide association studies (GWAS) and their application to pharmacogenomics. It adheres to the standard assumptions of this paradigm, such as the common disease-common variant hypothesis and the additive effect of genetic variants. It utilizes established methodologies for genomic data analysis

Separating the genetics of disease, treatment and treatment response using graphical modeling and large-scale electronic health records Read More »

Evidence for complex fixed points in pandemic data

Leave a Comment / Model Revolution, Paradigm Shift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-70238/v1_covered.pdf?c=1631840663 Stage Model Revolution / Paradigm Change Paradigm framing The preprint attempts to revolutionize the existing paradigm of epidemiological modeling, by introducing complex fixed points into the Renormalization Group (RG) framework. It challenges the conventional compartmental models and complex network diffusion techniques, which primarily focus on initial growth, by proposing a unified way to

Evidence for complex fixed points in pandemic data Read More »

Women and men exhibit distinct gut microbial profiles linked to colorectal cancer development

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.16.25327767v1.full.pdf Stage Normal Science Paradigm framing The paradigm of this research is the established understanding of the human gut microbiome's role in health and disease, specifically in the context of colorectal cancer (CRC). The study operates within the bounds of existing methodologies like metagenomic sequencing and statistical analysis, aiming to refine and expand upon

Women and men exhibit distinct gut microbial profiles linked to colorectal cancer development Read More »

Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5675275/v1/bdabe3e5-a9fc-4672-8f25-56cea5d59024.pdf?c=1735751343 Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of ophthalmology, specifically glaucoma management. It seeks to refine existing treatment strategies for acute angle-closure glaucoma (AACG). Highlights This research investigates the application of high-intensity focused ultrasound cycloplasty (UCP) for AACG, a relatively novel technique within the existing

Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty Read More »

Re-analyzed APOL1 kidney data support new ethics of ‘race’

Leave a Comment / medRxiv, Model Drift /

URL https://www.medrxiv.org/content/10.1101/2024.09.15.24313684v6.full.pdf Stage Model Drift Paradigm framing The dominant paradigm in nephrology research attributes disparities in kidney disease outcomes, particularly between Black and White patients, to genetic factors, notably variants of the APOL1 gene. This paradigm frames 'race' as a biologically meaningful category with direct causal links to health outcomes. Highlights This preprint challenges the

Re-analyzed APOL1 kidney data support new ethics of ‘race’ Read More »

Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.07.25327193v1.full.pdf Stage Normal Science / Model Drift Paradigm framing The current paradigm emphasizes that early revascularization is crucial for acute myocardial infarction (AMI) with cardiogenic shock, with both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) recognized as life-saving options. However, the choice between multi-vessel PCI and CABG in the specific setting

Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction Read More »

Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.655003v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the broader paradigm of cognitive neuroscience, specifically focusing on visual object recognition. Within this field, the dominant paradigm involves hierarchical processing of visual information in both biological and artificial systems. Highlights This preprint investigates the temporal correspondence between brain activity (measured via EEG) and

Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks Read More »

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation.

Leave a Comment / bioRxiv, Model Drift, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.16.654079v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of bioelectromagnetism, specifically focusing on the use of electric fields for neuromodulation. It uses established methodologies of computational bioelectromagnetism to analyze and model electric fields interaction with neural tissue. Highlights The preprint primarily contributes to "normal science" by

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation. Read More »