Preprint Watch

Precision Estimates of Longitudinal Brain Aging Capture Unexpected Individual Differences in One Year

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.02.21.25322553v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience and neurodegenerative disease research, which emphasizes the importance of longitudinal studies to understand brain aging and disease progression. It also accepts the established methods of brain imaging and morphometric analysis. Highlights This preprint presents a methodological refinement within the […]

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Patterns of Hepatocellular Carcinoma in Patients with or without Liver Cirrhosis using Computed Tomography in Tanzania: A hospital-based cross-sectional study

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.15.25327588v1.full.pdf Stage Normal Science Paradigm framing The paradigm in this study is the established understanding of Hepatocellular Carcinoma (HCC), its risk factors, diagnostic procedures, and typical presentations. It operates within the medical and oncological fields, relying on established diagnostic criteria, imaging techniques (CT), and statistical analysis. Highlights This research firmly falls within the "Normal

Patterns of Hepatocellular Carcinoma in Patients with or without Liver Cirrhosis using Computed Tomography in Tanzania: A hospital-based cross-sectional study Read More »

Nocturnal Glycemic Stability Index

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.18.25327867v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing is the use of Continuous Glucose Monitoring (CGM) systems and their data to improve the management of diabetes. The submitted preprint operates within this established paradigm by proposing a new metric, the Nocturnal Glycemic Stability Index (NGSI), derived from CGM data. Highlights This preprint firmly

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Association of Obesity with Kidney Function Outcomes in Heart Failure with Preserved Ejection Fraction

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.19.25327963v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of Heart Failure with Preserved Ejection Fraction (HFpEF) and its relationship with Chronic Kidney Disease (CKD), focusing on obesity as a potential contributing factor to kidney dysfunction in HFpEF. The research operates within the existing framework of cardio-renal interactions and established diagnostic

Association of Obesity with Kidney Function Outcomes in Heart Failure with Preserved Ejection Fraction Read More »

Differential Analysis Reveals Isoform Switching Following Pneumococcal Vaccination

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.03.09.642237v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the current paradigm of bioinformatics and transcriptomics, utilizing established RNA-seq technologies and analysis methods. It specifically focuses on the well-established concepts of differential gene expression and isoform switching. Highlights This preprint represents a clear example of normal science. It operates within the accepted paradigm

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CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.20.655027v1.full.pdf Stage Normal Science Paradigm framing ** The preprint operates within the established paradigm of G protein-coupled receptor (GPCR) signaling in immunology and chemotaxis. Specifically, it focuses on understanding the receptor targets and activation mechanisms of CXCL17, a chemokine with a debated receptor. ** Highlights ** This research falls primarily under "Normal Science" because

CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment Read More »

Navigating contradictions: Salmonella Typhimurium chemotaxis amidst conflicting stimuli of the intestinal environment

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.01.18.576330v4.full.pdf Stage Normal Science Paradigm framing Chemotaxis Highlights The preprint investigates the role of chemotaxis in *Salmonella Typhimurium* within the complex chemical environment of the gut, specifically focusing on the interaction between indole and other chemoeffectors. This research falls under normal science as it operates within the established paradigm of chemotaxis, seeking to refine

Navigating contradictions: Salmonella Typhimurium chemotaxis amidst conflicting stimuli of the intestinal environment Read More »

Constraints on maximum neutron star mass from proto-neutron star evolution

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6757777/v1_covered_31f5efe7-da24-4f9b-8d0b-4fac1e3d3fcc.pdf?c=1748452055 Stage Model Drift Paradigm framing The current paradigm for neutron stars is that they are composed primarily of neutrons, with some protons and leptons. There are a number of variations to this paradigm, including the presence of hyperons, kaons, or deconfined quarks. Highlights This preprint explores the impact of hyperons on the equation

Constraints on maximum neutron star mass from proto-neutron star evolution Read More »

Reappraisal of the place of cultivated plants in the carbon budget

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.17.654640v1.full.pdf Stage Model Drift Paradigm framing Carbon Budget and Climate Change Highlights The preprint "Reappraisal of the place of cultivated plants in the carbon budget" challenges the current paradigm of carbon budget accounting within the broader climate change discourse. The established paradigm largely neglects the carbon capture and storage contribution of annual crops, focusing

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Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654176v1.full.pdf Stage Model Drift Paradigm framing Nucleic acid quantification using enzyme-free isothermal amplification methods Highlights This preprint presents an attempt to replicate and validate the non-enzymatic isothermal strand displacement and amplification (NISDA) assay, a recently introduced method for nucleic acid detection. The authors’ inability to reproduce the sensitivity levels reported in the original NISDA

Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification Read More »