Preprint Watch

A Hypothalamus centered Pathogenesis of Heat Stroke Deaths- A Postmortem-Based Human Study

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323319v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of heat stroke pathophysiology, which emphasizes the role of thermoregulatory dysfunction and multi-organ failure. Highlights This research reinforces existing understanding by focusing on the anterior hypothalamus's specific role in heat stroke deaths. The study's methodology, involving post-mortem examination and histological analysis,

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Rhythmic Bacteria as Biomarkers for Circadian-Related Diseases

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URL https://assets-eu.researchsquare.com/files/rs-5723754/v1/8b1ea0d4-f870-45e1-920a-d212784a0dd8.pdf?c=1735815753 Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of human microbiome research, which acknowledges the crucial role of the gut microbiota in health and disease. It also accepts the established paradigm of circadian rhythms influencing physiological processes. Highlights This preprint investigates the potential link between rhythmic bacteria in the

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Tongue bite apparatus highlights functional innovation in a 310-million-year-old ray- finned fish

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.10.653277v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the established understanding of the evolution of feeding mechanisms in ray-finned fishes, specifically focusing on the development of the tongue bite. This includes the existing knowledge of the timing, anatomical variations, and phylogenetic distribution of this adaptation across different lineages. Highlights This preprint presents a

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From the COVID-19 Pandemic to the Mental Health of the Philippines: Modelling the Cascade of Disasters using an Influence Diagram

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URL https://www.medrxiv.org/content/10.1101/2025.05.14.25327598v1.full.pdf Stage Normal Science Paradigm framing Bayesian Networks and Influence Diagrams for Public Health Modeling Highlights This preprint operates within the established paradigm of applying Bayesian networks and influence diagrams to public health challenges. It doesn't challenge existing methodologies or propose radical new theories but extends existing models to a specific case study (mental

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Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiation

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.07.16.603656v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology, specifically focusing on post-transcriptional gene regulation mechanisms and their role in neuronal differentiation. It utilizes established techniques like RNA-seq and shRNA knockdown to investigate these processes. Highlights This research solidifies existing understanding within the field by providing a

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RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses

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URL https://www.biorxiv.org/content/10.1101/2022.01.18.476838v2.full.pdf Stage Normal Science Paradigm framing Genetics, Genomics, Molecular Biology, Immunology. Highlights This research operates within the established paradigm of molecular biology and genetics, specifically focusing on the role of gene mutations in disease. The study investigates the impact of RNF213 loss of function on vascular cells, aiming to understand its contribution to Moyamoya

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Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup

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URL https://www.medrxiv.org/content/10.1101/2025.03.18.25324188v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neurobiological models of PTSD, specifically focusing on structural alterations in the brain as related to PTSD symptom expression. It also sits within the broader paradigm of using large-scale neuroimaging datasets to investigate mental health disorders. Highlights This preprint represents a

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Hierarchical neurobiological changes in dorsolateral prefrontal cortex and subgenual anterior cingulate cortex connectivity induced by theta-burst stimulation

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URL https://www.medrxiv.org/content/10.1101/2025.05.23.25328212v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience, employing established methodologies like EEG, TMS, and computational modeling (DCM) to investigate brain function and connectivity. Specifically, it adheres to the paradigm that repetitive transcranial magnetic stimulation (rTMS), and particularly theta-burst stimulation (TBS), can induce lasting changes in brain

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf?c=1736735506 Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. The dominant paradigm is the cognitive development framework, specifically focused on executive functions, intertwined with the emerging paradigm of computational thinking in educational settings. Highlights This research firmly sits within the normal science stage. It operates under the established paradigm of

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DeepDrug2: A Germline-focused Graph Neural Network Framework for Alzheimer’s Drug Repurposing Validated by Electronic Health Records

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URL https://www.medrxiv.org/content/10.1101/2025.05.13.25327570v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of network-based drug repurposing for Alzheimer's disease, utilizing graph-based representations of biological interactions and applying machine learning for candidate prioritization. Highlights The study refines and extends the existing DeepDrug framework, introducing methodological improvements within the established paradigm. It shifts focus from

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