Preprint Watch

Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans

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URL https://www.biorxiv.org/content/10.1101/2025.03.21.644675v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the understanding of the phenotypic effects of ribosomal DNA (rDNA) copy number variation in model organisms. Highlights This preprint investigates the phenotypic consequences of natural rDNA copy number variation in *C. elegans*, a topic within the current paradigm of understanding the phenotypic effects of […]

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IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

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URL Stage https://www.biorxiv.org/content/10.1101/2025.05.09.652839v2 Normal Science Paradigm framing The preprint operates within the established paradigm of T cell-mediated immunity, specifically focusing on the role of IFNγ in cytotoxic CD8+ T cell function. This paradigm encompasses the understanding that CD8+ T cells recognize and eliminate infected or cancerous cells, and that cytokines like IFNγ play crucial roles

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Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

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URL https://www.biorxiv.org/content/10.1101/2025.05.21.654986v1.full.pdf Stage Normal Science Paradigm framing The current paradigm for treating genetic spermatogenic disorders includes hormone therapy and microdissection testicular sperm extraction (micro-TESE), which offer limited success. Gene therapies, specifically using CRISPR/Cas9, have shown promise in preclinical models but face challenges regarding off-target risks, ethical concerns, and limited clinical translatability. Highlights This preprint falls

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A male-transmitted B chromosome undergoes strong meiotic drag in females

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URL https://www.biorxiv.org/content/10.1101/2025.05.20.655026v1.full.pdf Stage Normal Science Paradigm framing The paper operates within the paradigm of Mendelian inheritance and chromosome theory, but focuses on an exception to the standard model: the non-Mendelian inheritance of B chromosomes. Highlights This research falls under normal science because it investigates a specific phenomenon (the inheritance of the PSR B chromosome) within

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CombiCTx: Screening diffusion gradients of anti-cancer drug combinations

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URL https://www.biorxiv.org/content/10.1101/2025.02.27.635465v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of in vitro cancer drug screening, specifically focusing on combination therapies. It adheres to the established methodology of evaluating drug efficacy and interactions, employing well-established techniques like microscopy and cell viability assays. Highlights This preprint presents a refinement of existing drug

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Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

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URL https://www.biorxiv.org/content/10.1101/2023.04.14.536948v3.full.pdf Stage Normal Science Paradigm framing The paper operates within the dominant paradigm of molecular biology, specifically focusing on the detailed mechanics of protein synthesis within the established framework of ribosomal function and the role of elongation factors. Highlights This preprint investigates a specific mechanism within the established paradigm of ribosomal protein synthesis. It

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Molecular Basis of Sodium Channel Inactivation

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URL https://www.biorxiv.org/content/10.1101/2025.05.22.655422v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of voltage-gated sodium channel function and inactivation, specifically focusing on the molecular mechanisms underlying fast inactivation. Highlights This research utilizes established experimental techniques like site-directed mutagenesis, voltage clamp fluorimetry, and electrophysiology to investigate a specific aspect of sodium channel inactivation. The

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When does rebleeding occur in subarachnoid hemorrhage? Revisiting rebleeding cases with a focus on blood pressure

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.23.25328264v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of subarachnoid hemorrhage (SAH) and its treatment, particularly focusing on the prevention and management of rebleeding. This includes established diagnostic methods (CT, CTA, DSA), treatment approaches (surgical clipping, interventional radiology), and the role of blood pressure management in influencing outcomes. Highlights This

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Stochastic tissue environment expands spatial limits of synaptic and astrocytic glutamate actions

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URL https://assets-eu.researchsquare.com/files/rs-6066377/v1/1d55e68c-96c0-47c7-a9b9-e031b37697e0.pdf?c=1748440685 Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience, which emphasizes the precise point-to-point transmission of glutamate at synapses. This paradigm is based on the understanding that high-affinity astrocytic transporters restrict glutamate spread, ensuring the specificity of synaptic signaling. Highlights This preprint presents a refined computational model of

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A Hypothalamus centered Pathogenesis of Heat Stroke Deaths- A Postmortem-Based Human Study

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URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323319v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of heat stroke pathophysiology, which emphasizes the role of thermoregulatory dysfunction and multi-organ failure. Highlights This research reinforces existing understanding by focusing on the anterior hypothalamus's specific role in heat stroke deaths. The study's methodology, involving post-mortem examination and histological analysis,

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