Preprint Watch

Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-03354-3.pdf Stage Normal Science Paradigm framing The preprint operates within the contemporary paradigm of molecular biology and immunology, specifically focusing on single-cell and spatial transcriptomics and imaging mass cytometry to understand disease mechanisms. Highlights This preprint represents a robust application of established techniques (single-cell RNA-seq, imaging mass cytometry, spatial transcriptomics) to investigate COVID-19 lung

Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population Read More »

The Role of Blood-Brain Barrier Dysfunction in Mediating Autoantibody and Immune Cell Entry in Pediatric Anti-NMDA Receptor Encephalitis: A Comparative Study

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6649929/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroimmunology, specifically focusing on the role of blood-brain barrier dysfunction in pediatric anti-NMDA receptor encephalitis. This paradigm accepts the well-established understanding of the immune system's role in neurological disorders and the importance of the blood-brain barrier in maintaining CNS homeostasis.

The Role of Blood-Brain Barrier Dysfunction in Mediating Autoantibody and Immune Cell Entry in Pediatric Anti-NMDA Receptor Encephalitis: A Comparative Study Read More »

Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-03347-2.pdf Stage Normal Science Paradigm framing The current paradigm for malaria vaccine development is shifting towards whole-organism approaches, moving beyond traditional subunit vaccines. This preprint operates within this evolving paradigm by investigating the efficacy of a genetically attenuated whole-parasite vaccine. Highlights This research contributes to the normal science phase of the paradigm shift by

Single immunization with genetically attenuated Pf∆mei2 (GA2) parasites by mosquito bite in controlled human malaria infection: a placebo-controlled randomized trial Read More »

Celiac disease in Afghanistan: prevalence of an existing but unknown disease to Afghans

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6675314/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of biomedical research, specifically within the established framework of immunology and gastroenterology as they pertain to Celiac Disease. It adheres to standard diagnostic procedures and utilizes established laboratory techniques. Highlights This preprint represents a typical example of normal science. The research

Celiac disease in Afghanistan: prevalence of an existing but unknown disease to Afghans Read More »

Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial

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URL https://www.nature.com/articles/s41591-025-03602-0.pdf Stage Normal Science Paradigm framing Nutritional Immunology, particularly the impact of diet on immune and metabolic function. Highlights This research operates within the established paradigm of nutritional immunology. It investigates a specific question (the impact of African heritage diets vs. Western diets) using standard methodologies (randomized controlled trial, multi-omics analysis). The study does

Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial Read More »

The Influenza-like Evolutionary Path of Respiratory RNA Viruses

Leave a Comment / Model Drift, Research Square /

URL https://www.researchsquare.com/article/rs-6707035/v1.pdf Stage Model Drift Paradigm framing The preprint operates predominantly within the established epidemiological paradigm of infectious disease modeling, exemplified by the SIR (Susceptible-Infected-Recovered) model. However, it introduces modifications that challenge certain assumptions of this paradigm, suggesting a state of Model Drift. Highlights This preprint introduces the SIRS-G model, an extension of the SIRS

The Influenza-like Evolutionary Path of Respiratory RNA Viruses Read More »

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

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URL https://www.nature.com/articles/s41591-025-03647-1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of cancer immunotherapy, specifically focusing on the role of the immune system in mediating responses to checkpoint blockade. It also touches upon the paradigm of viral immunology, particularly concerning the long-term effects of CMV infection on the immune system. Highlights This

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade Read More »

Current Therapeutic Strategies for Rasmussen Encephalitis: A Systematic Review of Functional Hemispherectomy and Immunotherapy in Pediatric Intractable Epilepsy

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6689486/v1.pdf Stage Normal Science / Model Drift Paradigm framing The dominant paradigm is the immunological understanding of Rasmussen Encephalitis (RE), encompassing the role of cytotoxic T-cells, inflammation, and the rationale for immunomodulatory therapies. The preprint also acknowledges the surgical paradigm, where hemispherectomy is the most effective intervention for seizure control. Highlights This systematic review

Current Therapeutic Strategies for Rasmussen Encephalitis: A Systematic Review of Functional Hemispherectomy and Immunotherapy in Pediatric Intractable Epilepsy Read More »

Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

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URL https://www.nature.com/articles/s41591-025-03699-3.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of immuno-oncology, specifically focusing on the role of T-cell exhaustion in ICI resistance and exploring host factors influencing treatment outcomes. Highlights This research falls under "normal science" as it investigates a specific problem (the role of mitochondrial genetics in ICI efficacy)

Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma Read More »

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

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URL https://www.researchsquare.com/article/rs-6759572/v1.pdf Stage Normal Science Paradigm framing The current paradigm in Type 1 diabetes (T1D) research centers around the autoimmune destruction of insulin-producing β-cells in the pancreas. This preprint works within this established paradigm. Highlights This research utilizes advanced 3D imaging techniques (light sheet fluorescent microscopy) to investigate the size, composition, and distribution of pancreatic

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Read More »