Preprint Watch

PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-02979-8.pdf Stage Normal Science Paradigm framing The dominant paradigm is the application of Chimeric Antigen Receptor (CAR) T cells for cancer treatment, specifically within the sub-paradigm of its use for solid tumors, exemplified by metastatic castration-resistant prostate cancer (mCRPC). Highlights This Phase 1 clinical trial investigates PSCA-CAR T cell therapy for mCRPC, falling squarely

PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial Read More »

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas

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URL https://www.nature.com/articles/s41591-024-03030-6.pdf Stage Normal Science Paradigm framing The current paradigm encompasses allograft dysfunction as an organ-specific process with varying molecular responses depending on the transplanted organ. Highlights This preprint operates within the existing paradigm of allograft dysfunction, but pushes the boundaries by exploring the concept of "pan-organ allograft dysfunction." It introduces the novel idea that

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas Read More »

Factor H related 2 levels dictate FHR dimer composition

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6130401/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of complement biology, specifically focusing on the role of Factor H and Factor H-Related proteins in regulating the alternative pathway of complement activation. Highlights This preprint focuses on refining the understanding of the dynamic interactions and dimerization of FHR proteins, particularly

Factor H related 2 levels dictate FHR dimer composition Read More »

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing

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URL https://www.researchsquare.com/article/rs-6299609/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and genomics, specifically focusing on single-cell RNA sequencing as a tool to understand cellular differentiation and lineage commitment. It also adheres to the established paradigm of using model organisms (dogs) to study human diseases. Highlights This research utilizes

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing Read More »

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

Leave a Comment / Model Drift, Normal Science /

URL https://www.nature.com/articles/s41591-024-03115-2.pdf Stage Normal Science / Model Drift Paradigm framing The current paradigm encompasses autoimmune mechanisms in type 1 diabetes (T1D) and the potential for immunomodulatory therapies. Highlights This phase 2 trial investigates ustekinumab, an approved drug for other autoimmune conditions, as a treatment for T1D in adolescents. The study operates within the existing paradigm

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial Read More »

Donor-reactive T cells and innate immune cells promote pig-to-human decedent xenograft rejection

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URL https://www.researchsquare.com/article/rs-6474835/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of transplantation immunology, specifically xenotransplantation. This paradigm acknowledges the organ shortage crisis and explores the use of animal organs as a potential solution. The current paradigm emphasizes the significant challenge posed by the immune response, both adaptive and innate, which leads

Donor-reactive T cells and innate immune cells promote pig-to-human decedent xenograft rejection Read More »

Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis

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URL https://www.nature.com/articles/s41591-024-03146-9.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of using Controlled Human Infection Models (CHIMs) for vaccine development and understanding disease pathology. This paradigm accepts the controlled infection of human volunteers as an ethical and scientifically valuable tool for advancing medical knowledge. Highlights This research firmly falls within the

Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis Read More »

MDA5 guards against infection by surveying cellular RNA homeostasis

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URL https://www.researchsquare.com/article/rs-6466919/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of immunology, specifically the framework of innate immune sensing of viral infections via pattern recognition receptors (PRRs). Highlights This research refines the current understanding of MDA5 activation. The prevailing model suggests that MDA5, a PRR, is activated by long viral dsRNA.

MDA5 guards against infection by surveying cellular RNA homeostasis Read More »

SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination

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URL https://www.nature.com/articles/s41591-024-03278-y.pdf Stage Normal Science Paradigm framing The preprint operates within the immunological paradigm of long-lived plasma cells (LLPCs) as the basis for durable humoral immunity. It specifically focuses on the role of bone marrow LLPCs in maintaining long-term antibody responses after vaccination. Highlights This preprint exemplifies normal science because it investigates a specific puzzle

SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination Read More »

AI-Driven CRISPR-Cas9 sgRNA Design for PDCD1, TRAC, and B2M Knockout to Improve CAR T Cell Therapy

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URL https://assets-eu.researchsquare.com/files/rs-6596407/v1/83cfb5f0-6d5a-4363-be23-415570bc1a7c.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of gene editing using CRISPR-Cas9 technology for CAR T-cell therapy. It adheres to the established methodology of sgRNA design and validation, focusing on improving existing techniques rather than proposing radical shifts. Highlights This preprint demonstrates normal science by refining established techniques

AI-Driven CRISPR-Cas9 sgRNA Design for PDCD1, TRAC, and B2M Knockout to Improve CAR T Cell Therapy Read More »