Preprint Watch

Exoplaneteers Keep Overestimating Sigma Significances

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.05392.pdf Stage Model Drift Paradigm framing Frequentist and Bayesian statistics in exoplanetary atmospheric studies. Highlights The preprint identifies a drift within the current paradigm of exoplanetary atmospheric characterization. Specifically, it addresses the misapplication of a statistical conversion (Sellke et al. 2001) by exoplaneteers. The authors argue that while the conversion itself is valid, its […]

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Cyanobacteria Join the Kahalalide Conversation: Genome and Metabolite Evidence for Structurally Related Peptides

Leave a Comment / chemRxiv, Normal Science /

URL https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/683e27bf1a8f9bdab54cfe62/original/cyanobacteria-join-the-kahalalide-conversation-genome-and-metabolite-evidence-for-structurally-related-peptides.pdf Stage Normal Science Paradigm framing Natural Products Chemistry, Genomics, and Bioinformatics Highlights This preprint focuses on the discovery and characterization of kahalalide Z5 (KZ5), a cyclic depsipeptide with structural similarities to the known anticancer compound kahalalide F. The research uses established techniques like NMR, MS, and chemical degradation, combined with AI-driven tools (SMART

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The largest diamonds are hosted in iron-rich substrate accreted at the base of the lithosphere

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6808081/v1/47d51c46-671e-47e9-afe4-f355d0e1744a.pdf Stage Normal Science Paradigm framing Diamond formation; Kimberlite magma interaction with deep lithospheric substrates Highlights This preprint investigates the origin of CLIPPIR diamonds, large and rare diamonds exhibiting unique characteristics. The authors explore the association between these diamonds and the composition of their host kimberlites, particularly focusing on olivine. Their findings demonstrate a

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Linear instability of plane Couette and Poiseuille flows

Leave a Comment / arXiv, Model Revolution /

URL https://arxiv.org/pdf/2506.04242.pdf Stage Model Revolution Paradigm framing Hydrodynamic Stability Highlights This preprint challenges the established paradigm in hydrodynamic stability regarding the linear instability of plane Couette and Poiseuille flows. The traditional assumption of longitudinal periodicity of disturbances is questioned, leading to new theoretical predictions for critical Reynolds numbers. The authors provide an alternative model that

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Two de novo transcriptome assemblies and functional annotations from juvenile cuttlefish (Sepia officinalis) under various metal and pCO2 exposure conditions

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.06.03.657592v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing of this research is genomics and molecular biology applied to ecotoxicology and environmental studies. Highlights This preprint presents two de novo transcriptome assemblies for the cuttlefish *Sepia officinalis*. This work fits within the "normal science" stage of Kuhn's paradigm cycle. The researchers are working within

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Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.06.13.598818v3.full.pdf Stage Normal Science Paradigm framing Cell Biology, Developmental Biology, Mitochondrial Inheritance, Chromosome Segregation Highlights This preprint investigates the role of Dynamin-related protein 1 (Drp1) in mitochondrial redistribution and partitioning during embryonic cleavage in mouse zygotes. The study uses established experimental techniques like Trim-Away, live imaging, and immunofluorescence to demonstrate that Drp1-mediated mitochondrial fragmentation

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Latent Variable Autoregression with Exogenous Inputs

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.04488.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of econometrics and time series analysis, specifically focusing on autoregressive models with exogenous inputs (ARX). It seeks to refine and extend this established model by incorporating latent variables. Highlights This preprint introduces (C)LARX, a novel variant of the ARX methodology. This

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From Bjorken Scaling to Scaling Violations

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.03383.pdf Stage Normal Science Paradigm framing The preprint operates within the paradigm of Quantum Chromodynamics (QCD) as the accepted theory of strong interactions. Highlights This preprint details the historical progression of understanding strong interactions, starting from the pre-paradigm struggles with perturbative pion-nucleon theory, to the model drift represented by approaches like current algebra and

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STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41586-025-09000-3.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of cancer immunology, specifically focusing on the role of dendritic cells (DCs) in mediating anti-tumor immunity, particularly in the context of immune checkpoint blockade (ICB) therapy. It explores the interplay between STAT3 and STAT5 signaling pathways in DCs and their impact

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PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-02979-8.pdf Stage Normal Science Paradigm framing The dominant paradigm is the application of Chimeric Antigen Receptor (CAR) T cells for cancer treatment, specifically within the sub-paradigm of its use for solid tumors, exemplified by metastatic castration-resistant prostate cancer (mCRPC). Highlights This Phase 1 clinical trial investigates PSCA-CAR T cell therapy for mCRPC, falling squarely

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