Preprint Watch

Discovery and validation of non-canonical antigens for Hepatocellular Carcinoma immunotherapy

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.06.08.25328714v1.full.pdf Stage Normal Science Paradigm framing The current paradigm in HCC treatment is immunotherapy, specifically leveraging T-cell recognition of tumor-specific antigens. This preprint operates within this established paradigm. Highlights This research focuses on the discovery and validation of non-canonical antigens (ncORFs) for HCC immunotherapy. It uses established methods like RNA sequencing, mass spectrometry, and

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AI Chatbots Versus Human Healthcare Professionals: A Systematic Review and Meta-Analysis of Empathy in Patient Care

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.06.09.25329258v1.full.pdf Stage Normal Science Paradigm framing The current paradigm is the importance of empathy in healthcare and patient outcomes. This preprint operates within this paradigm by investigating whether AI can also fulfill this important role. Highlights This systematic review and meta-analysis examines existing research comparing the perceived empathy of AI chatbots and human healthcare

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IDEIA: A Generative AI-Based System for Real-Time Editorial Ideation in Digital Journalism

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.07278.pdf Stage Normal Science Paradigm framing The preprint operates within the contemporary paradigm of digital journalism, which acknowledges the transformative impact of technology on news production and consumption. This paradigm emphasizes the need for speed, thematic relevance, visual appeal, and adaptability in journalistic practices. Within this broader framework, the study specifically addresses the emerging

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Happiness Finder: Exploring the Role of AI in Enhancing Well-Being During Four-Leaf Clover Searches

Leave a Comment / arXiv, Model Drift, Normal Science /

URL https://arxiv.org/pdf/2506.07393.pdf Stage Normal Science / Model Drift Paradigm framing The paradigm framing of the preprint is Human-Computer Interaction (HCI) and Positive Computing, specifically focusing on the intersection of AI, well-being, and the experience of search. It operates within the existing paradigm of using technology to enhance human experiences, but with a nuanced approach towards

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What is the Quark-Gluon Plasma made of?

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.07181.pdf Stage Model Drift Paradigm framing The current paradigm considers the quark-gluon plasma (QGP) as a strongly coupled liquid-like state composed of short-lived quasiparticles. This preprint evaluates the existing paradigm using both perturbative and non-perturbative methods including hard-thermal loop perturbation theory, lattice QCD, and the functional renormalization group. Highlights This preprint surveys the current

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NatADiff: Adversarial Boundary Guidance for Natural Adversarial Diffusion

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2505.20934.pdf Stage Normal Science Paradigm framing The preprint operates within the deep learning paradigm, specifically focusing on adversarial attacks and defenses within the image classification domain. It addresses the sub-paradigm of denoising diffusion probabilistic models for image generation and their application to adversarial sample creation. Highlights The preprint presents a novel method (NatADiff) for

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Agent Laboratory: Using LLM Agents as Research Assistants

Leave a Comment / arXiv, Model Revolution, Paradigm Shift /

URL https://arxiv.org/pdf/2501.04227.pdf Stage Model Revolution / Paradigm Change Paradigm framing The preprint operates within the paradigm of scientific research and publishing, specifically focusing on machine learning subfields. It introduces a potential shift by proposing LLM agents as active participants in the research process. Highlights The preprint "Agent Laboratory: Using LLM Agents as Research Assistants" presents

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Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2409.04109.pdf Stage Model Drift Paradigm framing The preprint operates within the established paradigm of using large language models (LLMs) for various Natural Language Processing (NLP) tasks, including idea generation. It specifically addresses the emergent area of research ideation using LLMs, an area still solidifying its own potential paradigms. Highlights This preprint presents a large-scale

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Shared Imagination: LLMs Hallucinate Alike

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2407.16604.pdf Stage Model Drift Paradigm framing The preprint operates within the dominant paradigm of natural language processing, specifically focusing on large language models (LLMs). The core assumptions of this paradigm include the effectiveness of transformer-based architectures, the importance of large-scale pre-training data, and the viability of instruction tuning and alignment techniques. Highlights The preprint

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Species synonyms depict changing but taxon-independent taxonomic praxis

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.04.28.651127v2.full.pdf Stage Normal Science Paradigm framing Evolutionary biology, taxonomy, and marine biology. Highlights This preprint analyzes the synonymization of marine species names over time. It operates within the widely accepted paradigms of evolutionary biology and taxonomy, specifically focusing on how species are defined and how our understanding of their diversity changes with time. The

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