Preprint Watch

Cracking the Undruggable: Discovery of a Mutation-Induced Cryptic Pocket in TP53 C238Y for Precision Oncology

Leave a Comment / Model Revolution, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6651642/v1/564bb168-231f-48c3-8fd7-d3cbf5797c65.pdf Stage Model Revolution Paradigm framing The established paradigm of mutant TP53 being "undruggable" due to a lack of stable binding pockets. Highlights This preprint presents compelling computational evidence challenging the current paradigm by demonstrating the existence of a mutation-induced cryptic pocket in the TP53 C238Y mutant. While the in silico findings are robust […]

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. Highlights The preprint investigates the effects of computational thinking (CT) training on executive functions in fifth-grade children. It falls under normal science because it operates within the established paradigms of cognitive science, educational science, and computer science. The study seeks to

Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children Read More »

Generative AI and Organizational Structure in the Knowledge Economy

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.00532.pdf Stage Model Drift Paradigm framing The preprint operates within the knowledge-based hierarchy paradigm of organizational structure, focusing on how expertise is distributed and utilized within firms. It examines the impact of a novel technology, Generative AI (GenAI), on this established paradigm. Highlights This preprint exhibits characteristics of both normal science and model drift.

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Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.30.656906v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular genetics and genomics, specifically focusing on the established understanding of gene mutations, RNA processing, and protein synthesis. It also adheres to the broader paradigm of Mendelian inheritance in explaining disease etiology. Highlights This preprint investigates the functional impact of

Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK Read More »

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.26.655791v1.full.pdf Stage Normal Science Paradigm framing The monoaminergic hypothesis of depression Highlights This research preprint investigates the effects of different antidepressant treatments on brain activity in mice, using c-fos expression as a marker. The study builds upon the established monoaminergic hypothesis of depression and aims to further elucidate the specific brain circuitry involved in

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin Read More »

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.27.656424v1.full.pdf Stage Normal Science Paradigm framing The paradigm in this research preprint about heart regeneration centers around the translation initiation factors and their impact on regenerative processes. Specifically, the role of eif4e1c, a cap-binding protein unique to fish, is investigated in relation to its canonical counterparts eif4ea and eif4eb. Highlights This preprint falls under

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration Read More »

The effects of broadband elicitor duration on transient-evoked otoacoustic emissions and a psychoacoustic measure of gain reduction

Leave a Comment / Normal Science /

URL https://assets-eu.researchsquare.com/files/rs-6753082/v1/c9de892e-c991-45d2-925f-89a332087d45.pdf?c=1748864291.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of auditory perception and cochlear mechanics, specifically focusing on the medial olivocochlear reflex (MOCR) and its role in gain reduction. It builds upon existing knowledge and methodologies within this field. Highlights This research investigates a specific aspect of MOCR function, namely

The effects of broadband elicitor duration on transient-evoked otoacoustic emissions and a psychoacoustic measure of gain reduction Read More »

Waves in ice

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2505.18635.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of wave-ice interactions, specifically focusing on the propagation and attenuation of ocean waves in various ice types (marginal ice zone, landfast ice, and ice shelves). This paradigm relies on established theories, such as linear wave theory, thin-plate elasticity for ice, and

Waves in ice Read More »

On the concentration distribution in turbulent thermals

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2505.21707.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of turbulent thermal theory, specifically focusing on the established understanding of entrainment, self-similarity, and the influence of Reynolds and Péclet numbers. Highlights This preprint investigates the concentration distribution within turbulent thermals, a topic that has not been systematically explored before. While

On the concentration distribution in turbulent thermals Read More »

Solving three core challenges in transient dynamics analysis of matrix population models

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.29.656837v1.full.pdf Stage Normal Science Paradigm framing The paper operates within the dominant paradigm of matrix population models in ecology and demography. Highlights This preprint presents a refinement of existing analytical tools within the established paradigm of matrix population models. It addresses specific technical challenges related to the interpretation of transient dynamics, proposing solutions like

Solving three core challenges in transient dynamics analysis of matrix population models Read More »