Preprint Watch

The Influenza-like Evolutionary Path of Respiratory RNA Viruses

Leave a Comment / Model Drift, Research Square /

URL https://www.researchsquare.com/article/rs-6707035/v1.pdf Stage Model Drift Paradigm framing The preprint operates predominantly within the established epidemiological paradigm of infectious disease modeling, exemplified by the SIR (Susceptible-Infected-Recovered) model. However, it introduces modifications that challenge certain assumptions of this paradigm, suggesting a state of Model Drift. Highlights This preprint introduces the SIRS-G model, an extension of the SIRS […]

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CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-025-03647-1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of cancer immunotherapy, specifically focusing on the role of the immune system in mediating responses to checkpoint blockade. It also touches upon the paradigm of viral immunology, particularly concerning the long-term effects of CMV infection on the immune system. Highlights This

CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade Read More »

Current Therapeutic Strategies for Rasmussen Encephalitis: A Systematic Review of Functional Hemispherectomy and Immunotherapy in Pediatric Intractable Epilepsy

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6689486/v1.pdf Stage Normal Science / Model Drift Paradigm framing The dominant paradigm is the immunological understanding of Rasmussen Encephalitis (RE), encompassing the role of cytotoxic T-cells, inflammation, and the rationale for immunomodulatory therapies. The preprint also acknowledges the surgical paradigm, where hemispherectomy is the most effective intervention for seizure control. Highlights This systematic review

Current Therapeutic Strategies for Rasmussen Encephalitis: A Systematic Review of Functional Hemispherectomy and Immunotherapy in Pediatric Intractable Epilepsy Read More »

Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-025-03699-3.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of immuno-oncology, specifically focusing on the role of T-cell exhaustion in ICI resistance and exploring host factors influencing treatment outcomes. Highlights This research falls under "normal science" as it investigates a specific problem (the role of mitochondrial genetics in ICI efficacy)

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3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6759572/v1.pdf Stage Normal Science Paradigm framing The current paradigm in Type 1 diabetes (T1D) research centers around the autoimmune destruction of insulin-producing β-cells in the pancreas. This preprint works within this established paradigm. Highlights This research utilizes advanced 3D imaging techniques (light sheet fluorescent microscopy) to investigate the size, composition, and distribution of pancreatic

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes Read More »

Trajectory of thirst level in critically ill oncology patients: A group-based trajectory model

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6488220/v1_covered_bf14d4c6-0551-46a0-bc69-380fce1a703d.pdf Stage Normal Science Paradigm framing The paradigm framing is thirst assessment and management in critically ill patients, particularly those in oncology. The dominant paradigm accepts the importance of thirst management and investigates its prevalence, intensity, and related factors in the ICU setting. This study operates within this paradigm by investigating thirst level trajectories

Trajectory of thirst level in critically ill oncology patients: A group-based trajectory model Read More »

Exploratory analysis of text duplication in peer-review reveals peer-review fraud and paper mills

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2202.03310.pdf Stage Normal Science Paradigm framing Research Integrity and Peer Review Highlights This preprint sits comfortably within the existing paradigm of research integrity. It explores a specific anomaly within the peer-review process—text duplication—and investigates this anomaly using established methods and tools within data science. While the preprint identifies potential misconduct, it doesn't fundamentally challenge

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Molecular signatures of chronic antibody-mediated rejection in human liver transplants

Leave a Comment / Normal Science, medRxiv /

URL https://www.medrxiv.org/content/10.1101/2024.02.08.24302515v3.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of transplant immunology, which recognizes chronic antibody-mediated rejection (cABMR) as a significant factor in liver transplant outcomes. Highlights This research refines the existing understanding of cABMR by providing a detailed molecular characterization. It identifies specific gene expression patterns associated with cABMR,

Molecular signatures of chronic antibody-mediated rejection in human liver transplants Read More »

Cost of institutional incentives for promoting cooperation in 2×2 games and collective risk games

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.02968.pdf Stage Normal Science Paradigm framing Evolutionary Game Theory, Institutional Economics, Cooperation Theory Highlights This preprint operates within the established paradigm of evolutionary game theory, specifically focusing on the well-defined problem of promoting cooperation through institutional incentives. The study explores established models like the Prisoner's Dilemma, Stag Hunt, and Collective Risk Game, utilizing standard

Cost of institutional incentives for promoting cooperation in 2×2 games and collective risk games Read More »

New level density parameter beyond Egidy-Bucurescu’s systematics

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.02322.pdf Stage Normal Science Paradigm framing Nuclear level density (NLD) within the back-shifted Fermi gas (BSFG) model of nuclear structure. Highlights This preprint focuses on refining existing methodologies for calculating level density parameters (LDPs) within the established BSFG model. The authors compile and analyze experimental data, comparing various existing parameterizations and proposing refined fits.

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