Preprint Watch

Two de novo transcriptome assemblies and functional annotations from juvenile cuttlefish (Sepia officinalis) under various metal and pCO2 exposure conditions

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.06.03.657592v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing of this research is genomics and molecular biology applied to ecotoxicology and environmental studies. Highlights This preprint presents two de novo transcriptome assemblies for the cuttlefish *Sepia officinalis*. This work fits within the "normal science" stage of Kuhn's paradigm cycle. The researchers are working within […]

Two de novo transcriptome assemblies and functional annotations from juvenile cuttlefish (Sepia officinalis) under various metal and pCO2 exposure conditions Read More »

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.06.13.598818v3.full.pdf Stage Normal Science Paradigm framing Cell Biology, Developmental Biology, Mitochondrial Inheritance, Chromosome Segregation Highlights This preprint investigates the role of Dynamin-related protein 1 (Drp1) in mitochondrial redistribution and partitioning during embryonic cleavage in mouse zygotes. The study uses established experimental techniques like Trim-Away, live imaging, and immunofluorescence to demonstrate that Drp1-mediated mitochondrial fragmentation

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes Read More »

Latent Variable Autoregression with Exogenous Inputs

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.04488.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of econometrics and time series analysis, specifically focusing on autoregressive models with exogenous inputs (ARX). It seeks to refine and extend this established model by incorporating latent variables. Highlights This preprint introduces (C)LARX, a novel variant of the ARX methodology. This

Latent Variable Autoregression with Exogenous Inputs Read More »

From Bjorken Scaling to Scaling Violations

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.03383.pdf Stage Normal Science Paradigm framing The preprint operates within the paradigm of Quantum Chromodynamics (QCD) as the accepted theory of strong interactions. Highlights This preprint details the historical progression of understanding strong interactions, starting from the pre-paradigm struggles with perturbative pion-nucleon theory, to the model drift represented by approaches like current algebra and

From Bjorken Scaling to Scaling Violations Read More »

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41586-025-09000-3.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of cancer immunology, specifically focusing on the role of dendritic cells (DCs) in mediating anti-tumor immunity, particularly in the context of immune checkpoint blockade (ICB) therapy. It explores the interplay between STAT3 and STAT5 signaling pathways in DCs and their impact

STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity Read More »

PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-02979-8.pdf Stage Normal Science Paradigm framing The dominant paradigm is the application of Chimeric Antigen Receptor (CAR) T cells for cancer treatment, specifically within the sub-paradigm of its use for solid tumors, exemplified by metastatic castration-resistant prostate cancer (mCRPC). Highlights This Phase 1 clinical trial investigates PSCA-CAR T cell therapy for mCRPC, falling squarely

PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial Read More »

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas

Leave a Comment / Normal Science /

URL https://www.nature.com/articles/s41591-024-03030-6.pdf Stage Normal Science Paradigm framing The current paradigm encompasses allograft dysfunction as an organ-specific process with varying molecular responses depending on the transplanted organ. Highlights This preprint operates within the existing paradigm of allograft dysfunction, but pushes the boundaries by exploring the concept of "pan-organ allograft dysfunction." It introduces the novel idea that

Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas Read More »

Factor H related 2 levels dictate FHR dimer composition

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6130401/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of complement biology, specifically focusing on the role of Factor H and Factor H-Related proteins in regulating the alternative pathway of complement activation. Highlights This preprint focuses on refining the understanding of the dynamic interactions and dimerization of FHR proteins, particularly

Factor H related 2 levels dictate FHR dimer composition Read More »

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6299609/v1.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and genomics, specifically focusing on single-cell RNA sequencing as a tool to understand cellular differentiation and lineage commitment. It also adheres to the established paradigm of using model organisms (dogs) to study human diseases. Highlights This research utilizes

Transcriptional landscape of canine hematopoiesis and cross-species comparisons revealed by single-cell RNA sequencing Read More »

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial

Leave a Comment / Model Drift, Normal Science /

URL https://www.nature.com/articles/s41591-024-03115-2.pdf Stage Normal Science / Model Drift Paradigm framing The current paradigm encompasses autoimmune mechanisms in type 1 diabetes (T1D) and the potential for immunomodulatory therapies. Highlights This phase 2 trial investigates ustekinumab, an approved drug for other autoimmune conditions, as a treatment for T1D in adolescents. The study operates within the existing paradigm

Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial Read More »