Preprint Watch

Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5675275/v1/bdabe3e5-a9fc-4672-8f25-56cea5d59024.pdf?c=1735751343 Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of ophthalmology, specifically glaucoma management. It seeks to refine existing treatment strategies for acute angle-closure glaucoma (AACG). Highlights This research investigates the application of high-intensity focused ultrasound cycloplasty (UCP) for AACG, a relatively novel technique within the existing […]

Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty Read More »

Re-analyzed APOL1 kidney data support new ethics of ‘race’

Leave a Comment / medRxiv, Model Drift /

URL https://www.medrxiv.org/content/10.1101/2024.09.15.24313684v6.full.pdf Stage Model Drift Paradigm framing The dominant paradigm in nephrology research attributes disparities in kidney disease outcomes, particularly between Black and White patients, to genetic factors, notably variants of the APOL1 gene. This paradigm frames 'race' as a biologically meaningful category with direct causal links to health outcomes. Highlights This preprint challenges the

Re-analyzed APOL1 kidney data support new ethics of ‘race’ Read More »

Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.07.25327193v1.full.pdf Stage Normal Science / Model Drift Paradigm framing The current paradigm emphasizes that early revascularization is crucial for acute myocardial infarction (AMI) with cardiogenic shock, with both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) recognized as life-saving options. However, the choice between multi-vessel PCI and CABG in the specific setting

Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction Read More »

Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.655003v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the broader paradigm of cognitive neuroscience, specifically focusing on visual object recognition. Within this field, the dominant paradigm involves hierarchical processing of visual information in both biological and artificial systems. Highlights This preprint investigates the temporal correspondence between brain activity (measured via EEG) and

Shared Hierarchical Representations Explain Temporal Correspondence Between Brain Activity and Deep Neural Networks Read More »

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation.

Leave a Comment / bioRxiv, Model Drift, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.16.654079v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of bioelectromagnetism, specifically focusing on the use of electric fields for neuromodulation. It uses established methodologies of computational bioelectromagnetism to analyze and model electric fields interaction with neural tissue. Highlights The preprint primarily contributes to "normal science" by

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation. Read More »

Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2024.12.24.24319598v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the paradigm of normative modeling in neuroimaging, which seeks to understand brain structure and function relative to established norms. Highlights This preprint presents a refinement (N³) of existing normative modeling techniques, aiming to address limitations in handling heterogeneity within study populations.

Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples Read More »

Draft genome and transcriptomic sequence data of three invasive insect species

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.12.02.626401v3.full.pdf Stage Normal Science Paradigm framing Genomics and Bioinformatics Highlights This preprint presents genomic and transcriptomic data for three invasive insect species. It falls under the "normal science" stage of Kuhn's paradigm cycle. The research operates within the established paradigms of genomics and bioinformatics, utilizing accepted methods like whole-genome sequencing, RNA-seq, and Hi-C sequencing.

Draft genome and transcriptomic sequence data of three invasive insect species Read More »

Fuzzy Recurrence Dynamics of Contrast Medium Extravasation in Computed Tomography

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323651v1.full.pdf Stage Normal Science / Model Drift Paradigm framing Established paradigm of computed tomography (CT) imaging analysis in trauma care. Highlights This preprint resides primarily within the normal science stage of Kuhn’s paradigm cycle. It operates within the established paradigm of CT imaging for trauma assessment but introduces a novel analytical approach (fuzzy recurrence

Fuzzy Recurrence Dynamics of Contrast Medium Extravasation in Computed Tomography Read More »

Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.08.29.610326v4.full.pdf Stage Normal Science Paradigm framing The current paradigm in auditory research is the power spectrum model of masking. The dominant theory is that behavioral frequency selectivity measurements should roughly correspond to cochlear frequency tuning, at least at lower sound levels. This assumes that the behavioral responses are largely driven by cochlear processes. Highlights

Otoacoustic emissions but not behavioral measurements predict cochlear-nerve frequency tuning in an avian vocal-communication specialist Read More »

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.06.28.601145v2.full.pdf Stage Normal Science Paradigm framing Current neurovascular coupling (NVC) and brain imaging paradigms Highlights The study uses established NVC concepts and advanced imaging techniques to investigate the role of astrocytes in NVC within the existing paradigm. There is no significant challenge to current paradigms but the study may inspire further studies. The research

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions Read More »