Preprint Watch

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2022.01.18.476838v2.full.pdf Stage Normal Science Paradigm framing Genetics, Genomics, Molecular Biology, Immunology. Highlights This research operates within the established paradigm of molecular biology and genetics, specifically focusing on the role of gene mutations in disease. The study investigates the impact of RNF213 loss of function on vascular cells, aiming to understand its contribution to Moyamoya […]

RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses Read More »

Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.03.18.25324188v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neurobiological models of PTSD, specifically focusing on structural alterations in the brain as related to PTSD symptom expression. It also sits within the broader paradigm of using large-scale neuroimaging datasets to investigate mental health disorders. Highlights This preprint represents a

Structural covariance of early visual cortex is negatively associated with PTSD symptoms: A Mega-Analysis from the ENIGMA PTSD workgroup Read More »

Hierarchical neurobiological changes in dorsolateral prefrontal cortex and subgenual anterior cingulate cortex connectivity induced by theta-burst stimulation

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.23.25328212v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience, employing established methodologies like EEG, TMS, and computational modeling (DCM) to investigate brain function and connectivity. Specifically, it adheres to the paradigm that repetitive transcranial magnetic stimulation (rTMS), and particularly theta-burst stimulation (TBS), can induce lasting changes in brain

Hierarchical neurobiological changes in dorsolateral prefrontal cortex and subgenual anterior cingulate cortex connectivity induced by theta-burst stimulation Read More »

Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf?c=1736735506 Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. The dominant paradigm is the cognitive development framework, specifically focused on executive functions, intertwined with the emerging paradigm of computational thinking in educational settings. Highlights This research firmly sits within the normal science stage. It operates under the established paradigm of

Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children Read More »

DeepDrug2: A Germline-focused Graph Neural Network Framework for Alzheimer’s Drug Repurposing Validated by Electronic Health Records

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.13.25327570v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of network-based drug repurposing for Alzheimer's disease, utilizing graph-based representations of biological interactions and applying machine learning for candidate prioritization. Highlights The study refines and extends the existing DeepDrug framework, introducing methodological improvements within the established paradigm. It shifts focus from

DeepDrug2: A Germline-focused Graph Neural Network Framework for Alzheimer’s Drug Repurposing Validated by Electronic Health Records Read More »

Changes in public perception of AI in healthcare after exposure to ChatGPT

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.01.23.25321048v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the positive impact of exposure to user-friendly AI tools on the public perception of AI in healthcare. Highlights This preprint presents research findings within the existing paradigm of understanding public perception of AI and how first-hand experience can shape these perceptions. The research does not

Changes in public perception of AI in healthcare after exposure to ChatGPT Read More »

Precision Estimates of Longitudinal Brain Aging Capture Unexpected Individual Differences in One Year

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.02.21.25322553v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience and neurodegenerative disease research, which emphasizes the importance of longitudinal studies to understand brain aging and disease progression. It also accepts the established methods of brain imaging and morphometric analysis. Highlights This preprint presents a methodological refinement within the

Precision Estimates of Longitudinal Brain Aging Capture Unexpected Individual Differences in One Year Read More »

Patterns of Hepatocellular Carcinoma in Patients with or without Liver Cirrhosis using Computed Tomography in Tanzania: A hospital-based cross-sectional study

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.15.25327588v1.full.pdf Stage Normal Science Paradigm framing The paradigm in this study is the established understanding of Hepatocellular Carcinoma (HCC), its risk factors, diagnostic procedures, and typical presentations. It operates within the medical and oncological fields, relying on established diagnostic criteria, imaging techniques (CT), and statistical analysis. Highlights This research firmly falls within the "Normal

Patterns of Hepatocellular Carcinoma in Patients with or without Liver Cirrhosis using Computed Tomography in Tanzania: A hospital-based cross-sectional study Read More »

Nocturnal Glycemic Stability Index

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.18.25327867v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing is the use of Continuous Glucose Monitoring (CGM) systems and their data to improve the management of diabetes. The submitted preprint operates within this established paradigm by proposing a new metric, the Nocturnal Glycemic Stability Index (NGSI), derived from CGM data. Highlights This preprint firmly

Nocturnal Glycemic Stability Index Read More »

Association of Obesity with Kidney Function Outcomes in Heart Failure with Preserved Ejection Fraction

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.19.25327963v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of Heart Failure with Preserved Ejection Fraction (HFpEF) and its relationship with Chronic Kidney Disease (CKD), focusing on obesity as a potential contributing factor to kidney dysfunction in HFpEF. The research operates within the existing framework of cardio-renal interactions and established diagnostic

Association of Obesity with Kidney Function Outcomes in Heart Failure with Preserved Ejection Fraction Read More »