Preprint Watch

CombiCTx: Screening diffusion gradients of anti-cancer drug combinations

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.02.27.635465v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of in vitro cancer drug screening, specifically focusing on combination therapies. It adheres to the established methodology of evaluating drug efficacy and interactions, employing well-established techniques like microscopy and cell viability assays. Highlights This preprint presents a refinement of existing drug […]

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Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

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URL https://www.biorxiv.org/content/10.1101/2023.04.14.536948v3.full.pdf Stage Normal Science Paradigm framing The paper operates within the dominant paradigm of molecular biology, specifically focusing on the detailed mechanics of protein synthesis within the established framework of ribosomal function and the role of elongation factors. Highlights This preprint investigates a specific mechanism within the established paradigm of ribosomal protein synthesis. It

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Molecular Basis of Sodium Channel Inactivation

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URL https://www.biorxiv.org/content/10.1101/2025.05.22.655422v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of voltage-gated sodium channel function and inactivation, specifically focusing on the molecular mechanisms underlying fast inactivation. Highlights This research utilizes established experimental techniques like site-directed mutagenesis, voltage clamp fluorimetry, and electrophysiology to investigate a specific aspect of sodium channel inactivation. The

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When does rebleeding occur in subarachnoid hemorrhage? Revisiting rebleeding cases with a focus on blood pressure

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.23.25328264v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of subarachnoid hemorrhage (SAH) and its treatment, particularly focusing on the prevention and management of rebleeding. This includes established diagnostic methods (CT, CTA, DSA), treatment approaches (surgical clipping, interventional radiology), and the role of blood pressure management in influencing outcomes. Highlights This

When does rebleeding occur in subarachnoid hemorrhage? Revisiting rebleeding cases with a focus on blood pressure Read More »

Stochastic tissue environment expands spatial limits of synaptic and astrocytic glutamate actions

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URL https://assets-eu.researchsquare.com/files/rs-6066377/v1/1d55e68c-96c0-47c7-a9b9-e031b37697e0.pdf?c=1748440685 Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of neuroscience, which emphasizes the precise point-to-point transmission of glutamate at synapses. This paradigm is based on the understanding that high-affinity astrocytic transporters restrict glutamate spread, ensuring the specificity of synaptic signaling. Highlights This preprint presents a refined computational model of

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A Hypothalamus centered Pathogenesis of Heat Stroke Deaths- A Postmortem-Based Human Study

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URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323319v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of heat stroke pathophysiology, which emphasizes the role of thermoregulatory dysfunction and multi-organ failure. Highlights This research reinforces existing understanding by focusing on the anterior hypothalamus's specific role in heat stroke deaths. The study's methodology, involving post-mortem examination and histological analysis,

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Rhythmic Bacteria as Biomarkers for Circadian-Related Diseases

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URL https://assets-eu.researchsquare.com/files/rs-5723754/v1/8b1ea0d4-f870-45e1-920a-d212784a0dd8.pdf?c=1735815753 Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of human microbiome research, which acknowledges the crucial role of the gut microbiota in health and disease. It also accepts the established paradigm of circadian rhythms influencing physiological processes. Highlights This preprint investigates the potential link between rhythmic bacteria in the

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Tongue bite apparatus highlights functional innovation in a 310-million-year-old ray- finned fish

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URL https://www.biorxiv.org/content/10.1101/2025.05.10.653277v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the established understanding of the evolution of feeding mechanisms in ray-finned fishes, specifically focusing on the development of the tongue bite. This includes the existing knowledge of the timing, anatomical variations, and phylogenetic distribution of this adaptation across different lineages. Highlights This preprint presents a

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From the COVID-19 Pandemic to the Mental Health of the Philippines: Modelling the Cascade of Disasters using an Influence Diagram

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URL https://www.medrxiv.org/content/10.1101/2025.05.14.25327598v1.full.pdf Stage Normal Science Paradigm framing Bayesian Networks and Influence Diagrams for Public Health Modeling Highlights This preprint operates within the established paradigm of applying Bayesian networks and influence diagrams to public health challenges. It doesn't challenge existing methodologies or propose radical new theories but extends existing models to a specific case study (mental

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Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiation

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URL https://www.biorxiv.org/content/10.1101/2024.07.16.603656v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology, specifically focusing on post-transcriptional gene regulation mechanisms and their role in neuronal differentiation. It utilizes established techniques like RNA-seq and shRNA knockdown to investigate these processes. Highlights This research solidifies existing understanding within the field by providing a

Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiation Read More »