Preprint Watch

Attention-based deep learning for analysis of pathology images and gene expression data in lung squamous premalignant lesions

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.06.06.25328492v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of using deep learning, specifically attention-based models, for image analysis and multi-modal data integration in computational pathology. It adheres to the established practices of training and validating models on large datasets, using metrics like AUROC and AUPR for evaluation, and exploring […]

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Breaking Bad Molecules: Are MLLMs Ready for Structure-Level Molecular Detoxification?

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2506.10912.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of applying machine learning, specifically Multimodal Large Language Models (MLLMs), to address challenges in drug discovery and development. It adheres to the established paradigm of using computational methods for molecular design and property prediction. Highlights This preprint presents a novel benchmark

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Large-scale skin metagenomics reveals extensive prevalence, coordination, and functional adaptation of skin microbiome dermotypes across body sites

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.04.24.650393v2.full.pdf Stage Normal Science Paradigm framing Human Microbiome Project (HMP) Highlights This research expands upon the established paradigm of the Human Microbiome Project by focusing on in-depth characterization of the skin microbiome and introducing the novel concept of "dermotypes". While acknowledging the existing knowledge of site-specific differences in skin microbial composition, the study builds

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A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.06.04.657956v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of metabolic memory in diabetic heart disease, specifically focusing on the role of O-GlcNAcylation. Highlights This research uses established models and methodologies to investigate a specific aspect of metabolic memory within the existing paradigm. The study builds upon prior knowledge and

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Understanding how adolescents experience violence and its perceived impacts on mental health: A qualitative study across 13 countries

Leave a Comment / Normal Science /

URL https://assets-eu.researchsquare.com/files/rs-6822872/v1/a7b11fcd-1a77-4fda-9adb-b5d0edb6de80.pdf?c=1749114878 Stage Normal Science Paradigm framing The preprint operates within the paradigm of social and behavioral sciences, specifically focusing on public health and adolescent psychology. It utilizes established methodologies like qualitative research and thematic analysis, aligning with accepted norms within the field. Highlights This research contributes to the existing body of knowledge on adolescent

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Direct observation of layer skyrmions in twisted WSe2 bilayers

Leave a Comment / arXiv, Normal Science /

URL https://www.researchsquare.com/article/rs-4652186/v1.pdf?c=1746183939000 Stage Normal Science Paradigm framing Condensed Matter Physics, two-dimensional materials, specifically twisted bilayer WSe2. The dominant paradigm is the study of quantum phenomena arising from topology and correlation in moiré materials. Highlights This preprint presents a direct observation of a layer-skyrmion texture using scanning tunneling microscopy/spectroscopy (STM/STS), applied to twisted WSe2 bilayers. This

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Understanding how adolescents experience violence and its perceived impacts on mental health: A qualitative study across 13 countries

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6822872/v1.pdf?c=1749129278000 Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of social and behavioral sciences, specifically focusing on the well-established link between violence exposure and mental health outcomes in adolescents. It also acknowledges the socio-ecological model as a framework for understanding violence. Highlights This research firmly falls within the 'Normal Science'

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Buzzed but not elated? Effect of ethanol on cognitive judgement bias in honeybees

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.06.05.658067v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing of the preprint is the study of animal behavior and cognition, specifically focusing on how affective states can be measured and influenced. The dominant paradigm accepts that invertebrates, such as honeybees, can experience affective states and uses methods like Cognitive Judgement Bias (CJB) tests to

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Preprinting the COVID-19 pandemic

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2020.05.22.111294v3.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of scientific communication, which traditionally involves peer-reviewed journal publications. However, it acknowledges a shift towards preprints, particularly in the context of the COVID-19 pandemic. Highlights This preprint examines the role of preprints in disseminating COVID-19 research. It analyzes preprints on bioRxiv

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A Plasma Torus Around a Young Low-Mass Star

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2506.09116.pdf Stage Model Drift Paradigm framing The preprint operates within the paradigm of stellar magnetism and its influence on circumstellar material. This paradigm assumes that magnetic fields play a key role in shaping the environment around stars, especially young, rapidly rotating ones. Highlights This preprint presents evidence for a plasma torus around a young,

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