Preprint Watch

Optimizing information flow in Gene Regulatory Networks: a geometric perspective

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2509.08167.pdf Stage Normal Science Paradigm framing The paper is situated within the paradigm of systems biology, where Gene Regulatory Networks (GRNs) are understood as complex dynamical systems. It specifically builds upon the framework that models cellular processes using stochastic dynamics (Fokker-Planck and Langevin equations) and information theory, conceptualized through constructs like the Waddington epigenetic […]

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What makes a mycoparasite? Similarities between fungi that attack other fungi and fungal and oomycete plant pathogens based on structural homology of their candidate effectors

Leave a Comment / Model Revolution, Research Square /

URL https://www.researchsquare.com/article/rs-7759314/v1.pdf Stage Model Revolution Paradigm framing The paper is situated within mycology and microbial ecology. The prevailing paradigm for understanding mycoparasitism (fungi parasitizing other fungi) has been largely descriptive, relying on empirical observation and ecological classification. This research introduces a new conceptual model by framing mycoparasitism within the well-established molecular paradigm of plant-pathogen interactions.

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Cloud structure and young star distribution in the Dragonfish complex

Leave a Comment / arXiv, Model Drift /

URL https://arxiv.org/pdf/2406.18432.pdf Stage Model Drift Paradigm framing The paper operates within the established paradigm of star formation, where stars are born from the turbulent, fractal structures of interstellar gas clouds. This framework predicts that the spatial distribution of young stars should reflect the fractal structure of their parent cloud, allowing for a quantitative comparison using

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Universal Deep Research: Bring Your Own Model and Strategy

arXiv, Model Revolution /

URL https://arxiv.org/pdf/2509.00244.pdf Stage Model Revolution Paradigm framing The paper addresses the emerging paradigm of AI-powered agentic systems, specifically Deep Research Tools (DRTs) that leverage Large Language Models for automated information synthesis. The dominant paradigm involves DRTs with fixed, developer-defined research strategies. This work challenges that model by identifying a crisis of rigidity and lack of

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Hybrid Switched-capacitor Three-phase Direct AC-AC Converter with Adjustable Output Voltage

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-7760201/v1_covered_5cfbd94a-81f9-4cab-9358-80e228b82f0c.pdf Stage Normal Science Paradigm framing The research is situated within the power electronics field, specifically addressing the paradigm of direct AC-AC power conversion using Switched-Capacitor (SC) converter topologies. This paradigm aims to develop compact, efficient, and transformer-less voltage converters. The paper works to extend this paradigm by solving the puzzle of achieving adjustable

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New charged dynamical particles in spatially flat FLRW space-times

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2510.03444.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of theoretical physics, specifically the application of Einstein-Maxwell theory to cosmology. The foundational framework is the Friedmann-Lemaître-Robertson-Walker (FLRW) model of the universe. The paper's contribution is to find new, exact solutions to the governing equations of this paradigm to describe a

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Room-Temperature Superconductivity at 298 K in Ternary La-Sc-H System at High-pressure Conditions

Leave a Comment / Model Revolution, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-7755852/v1/0c8d2926-46f8-41bb-bd8b-ca9652f0b42e.pdf Stage Model Revolution Paradigm framing The research operates within the established paradigm of condensed matter physics that seeks high-temperature superconductivity in hydrogen-rich materials under extreme pressure. This paradigm posits that hydrogen-based clathrate structures can achieve high critical temperatures (Tc). This paper extends the paradigm from binary (e.g., LaH10) to ternary systems (La-Sc-H), proposing

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Global human myeloid replacement with peripheral progenitors induces interferonopathy and neurodegeneration

Leave a Comment / Model Crisis, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-7762822/v1/992f5429-50f2-4255-9eea-73dfc72d2753.pdf Stage Model Crisis Paradigm framing The research addresses the paradigm in neuroimmunology and regenerative medicine which posits that replacing dysfunctional brain microglia with healthy, peripherally-derived hematopoietic stem cells (HSCs) is a viable therapeutic strategy for neurodegenerative diseases. This prevailing model is largely founded on evidence from murine studies suggesting that such replacement is

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Cosmological tensions in the era of precision cosmology: Insights from Tensions in Cosmology 2025

Leave a Comment / arXiv, Model Crisis /

URL https://arxiv.org/pdf/2509.25288.pdf Stage Model Crisis Paradigm framing The paper operates within the established ΛCDM (Lambda-Cold Dark Matter) or "concordance model" of cosmology. This paradigm, which posits a universe dominated by a cosmological constant and cold dark matter, has successfully explained cosmological observations for decades. The paper's focus is on the growing observational challenges to this

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Predictive Emotional Selfhood in Articial Minds (PESAM): A Unied and Synergistic Variational Framework

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-7713015/v1_covered_edbb151e-5647-4e84-9b22-f21605513872.pdf Stage Model Drift Paradigm framing The preprint operates within the paradigm of the Active Inference framework and the Free Energy Principle in computational neuroscience and artificial intelligence. This paradigm posits that intelligent agents perceive, act, and learn by continuously minimizing prediction error (or surprise) about their sensory inputs. The paper specifically addresses the

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