Preprint Watch

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.15.654070v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of oxygen sensing in vertebrates, which involves specialized respiratory chemoreceptors. This paradigm includes the established role of acetylcholine (ACh) in oxygen sensing in the mammalian carotid body and pulmonary neuroepithelial bodies (NEBs), as well as the recognized presence and role of serotonin […]

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Stimulant medications affect arousal and reward, not attention

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654915v2.full.pdf Stage Model Drift Paradigm framing The dominant paradigm is the attention-network model of stimulant action. This model suggests that stimulants primarily improve attention by directly modulating attention networks in the brain. Highlights This preprint challenges the prevailing paradigm by presenting evidence suggesting that the primary effect of stimulants is on arousal and reward

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Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.16.654440v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the established use of chemotherapy, radiotherapy, and surgery for Ewing sarcoma. Highlights This preprint presents research on oncolytic Maraba virus MG1 as a potential treatment for Ewing sarcoma. The research is conducted within the framework of existing cancer treatment paradigms, exploring a new therapeutic

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A Collaborative Approach to Improving Missense Mutational Effect Predictions in Oncoproteins

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.15.25327738v1.full.pdf Stage Normal Science Paradigm framing The current paradigm for predicting the effects of missense mutations relies on a variety of computational tools, each with its own strengths and weaknesses. This paper operates within this established paradigm but seeks to refine it. Highlights This preprint presents the "APE score," a novel ensemble metric that

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Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.15.654311v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and proteomics, specifically focusing on the identification and quantification of proteins in blood as a means to understand physiological and pathological states. Highlights This research represents a significant contribution to normal science within the field of blood proteomics.

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The Perspectivist Paradigm Shift: Assumptions and Challenges of Capturing Human Labels

Leave a Comment / arXiv, Model Crisis, Model Drift /

URL Stage https://arxiv.org/abs/2405.05860 Model Drift/Model Crisis Paradigm framing The preprint focuses on the paradigm shift in data labeling from the traditional “ground truth” paradigm to the “perspectivist” paradigm, particularly within the field of Natural Language Processing. Highlights The preprint argues for a “perspectivist turn” in machine learning, challenging the established paradigm that treats annotator disagreement

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