Preprint Watch

Epigenetic mediation may explain intergenerational associations between maternal lifestyle and birth weight of offsprings – Findings from the NorthPop prospective birth cohort

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.06.01.25328723v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of DOHaD (Developmental Origins of Health and Disease), specifically focusing on the role of epigenetics in mediating the relationship between maternal lifestyle during pregnancy and offspring birth weight. It utilizes established methodologies of statistical analysis and DNA methylation assessment, working within […]

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Green Synthesis of Cuo Nanoparticles Using Gloriosa Superba L. Extract by Phytochemical Analysis and Antimicrobial Applications

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6764786/v1/2dc5cde3-f6c7-4b77-b079-dcfd5e9b9fd2.pdf?c=1748866802.pdf Stage Normal Science Paradigm framing Nanotechnology, Green Chemistry, Material Science, Microbiology. Highlights The preprint investigates the green synthesis of CuO nanoparticles using Gloriosa superba L. extract. This research falls under the normal science stage because it operates within the established paradigm of nanotechnology and green chemistry. It explores a specific application of existing

Green Synthesis of Cuo Nanoparticles Using Gloriosa Superba L. Extract by Phytochemical Analysis and Antimicrobial Applications Read More »

Disentangling objects′ contextual associations from perceptual and conceptual attributes using time-resolved neural decoding

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.29.656895v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of cognitive neuroscience, specifically focusing on visual object recognition and its neural underpinnings. It adheres to the dominant assumption that object knowledge is represented in a distributed and dynamic manner in the brain, with perceptual and conceptual features playing distinct roles.

Disentangling objects′ contextual associations from perceptual and conceptual attributes using time-resolved neural decoding Read More »

Slow-Timescale Regulation of Dopamine Release and Mating Drive over Days

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.29.656898v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of neuroendocrine regulation of behavior, specifically focusing on the role of dopamine in modulating mating drive. Highlights This research utilizes established experimental techniques like fluorescence lifetime imaging microscopy, electrophysiology, and optogenetics to investigate a specific aspect of dopamine’s function in mating

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Genetic signatures of bipolar disorder course specifiers

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.17.25327825v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of psychiatric genetics, which emphasizes the role of genetic factors in the development and manifestation of mental disorders. It also adheres to the dimensional approach to psychopathology, viewing mental illness as existing on a spectrum rather than as discrete categories. Highlights

Genetic signatures of bipolar disorder course specifiers Read More »

Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.16.654552v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of using functional magnetic resonance imaging (fMRI) and network neuroscience to study brain function and disorders. Specifically, it focuses on the sub-paradigm of dynamic functional connectivity (DFC) analysis, which has gained traction in recent years as a way to capture the

Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI Read More »

Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.03.21.644675v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the understanding of the phenotypic effects of ribosomal DNA (rDNA) copy number variation in model organisms. Highlights This preprint investigates the phenotypic consequences of natural rDNA copy number variation in *C. elegans*, a topic within the current paradigm of understanding the phenotypic effects of

Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans Read More »

IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

Leave a Comment / bioRxiv, Normal Science /

URL Stage https://www.biorxiv.org/content/10.1101/2025.05.09.652839v2 Normal Science Paradigm framing The preprint operates within the established paradigm of T cell-mediated immunity, specifically focusing on the role of IFNγ in cytotoxic CD8+ T cell function. This paradigm encompasses the understanding that CD8+ T cells recognize and eliminate infected or cancerous cells, and that cytokines like IFNγ play crucial roles

IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells Read More »

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.21.654986v1.full.pdf Stage Normal Science Paradigm framing The current paradigm for treating genetic spermatogenic disorders includes hormone therapy and microdissection testicular sperm extraction (micro-TESE), which offer limited success. Gene therapies, specifically using CRISPR/Cas9, have shown promise in preclinical models but face challenges regarding off-target risks, ethical concerns, and limited clinical translatability. Highlights This preprint falls

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders Read More »

A male-transmitted B chromosome undergoes strong meiotic drag in females

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.20.655026v1.full.pdf Stage Normal Science Paradigm framing The paper operates within the paradigm of Mendelian inheritance and chromosome theory, but focuses on an exception to the standard model: the non-Mendelian inheritance of B chromosomes. Highlights This research falls under normal science because it investigates a specific phenomenon (the inheritance of the PSR B chromosome) within

A male-transmitted B chromosome undergoes strong meiotic drag in females Read More »