Preprint Watch

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.26.655791v1.full.pdf Stage Normal Science Paradigm framing The monoaminergic hypothesis of depression Highlights This research preprint investigates the effects of different antidepressant treatments on brain activity in mice, using c-fos expression as a marker. The study builds upon the established monoaminergic hypothesis of depression and aims to further elucidate the specific brain circuitry involved in […]

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Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.27.656424v1.full.pdf Stage Normal Science Paradigm framing The paradigm in this research preprint about heart regeneration centers around the translation initiation factors and their impact on regenerative processes. Specifically, the role of eif4e1c, a cap-binding protein unique to fish, is investigated in relation to its canonical counterparts eif4ea and eif4eb. Highlights This preprint falls under

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration Read More »

The effects of broadband elicitor duration on transient-evoked otoacoustic emissions and a psychoacoustic measure of gain reduction

Leave a Comment / Normal Science /

URL https://assets-eu.researchsquare.com/files/rs-6753082/v1/c9de892e-c991-45d2-925f-89a332087d45.pdf?c=1748864291.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of auditory perception and cochlear mechanics, specifically focusing on the medial olivocochlear reflex (MOCR) and its role in gain reduction. It builds upon existing knowledge and methodologies within this field. Highlights This research investigates a specific aspect of MOCR function, namely

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Waves in ice

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2505.18635.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of wave-ice interactions, specifically focusing on the propagation and attenuation of ocean waves in various ice types (marginal ice zone, landfast ice, and ice shelves). This paradigm relies on established theories, such as linear wave theory, thin-plate elasticity for ice, and

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On the concentration distribution in turbulent thermals

Leave a Comment / arXiv, Normal Science /

URL https://arxiv.org/pdf/2505.21707.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of turbulent thermal theory, specifically focusing on the established understanding of entrainment, self-similarity, and the influence of Reynolds and Péclet numbers. Highlights This preprint investigates the concentration distribution within turbulent thermals, a topic that has not been systematically explored before. While

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Solving three core challenges in transient dynamics analysis of matrix population models

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URL https://www.biorxiv.org/content/10.1101/2025.05.29.656837v1.full.pdf Stage Normal Science Paradigm framing The paper operates within the dominant paradigm of matrix population models in ecology and demography. Highlights This preprint presents a refinement of existing analytical tools within the established paradigm of matrix population models. It addresses specific technical challenges related to the interpretation of transient dynamics, proposing solutions like

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Cooperation Destabilizes Communities, but Competition Pays the Price

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URL https://www.biorxiv.org/content/10.1101/2023.12.26.573354v2.full.pdf Stage Normal Science Paradigm framing Community Ecology, Population Dynamics, and the paradigm of diversity-stability relationships within ecological communities. Highlights This preprint investigates a well-established problem within community ecology: the seemingly paradoxical prevalence of cooperation in natural communities despite theoretical predictions that cooperation destabilizes communities. This places the research firmly within the 'normal science'

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The MagMa Study: Quantum Magnetocardiography in Non-Ischemic Cardiomyopathy

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.29.25328567v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of evidence-based medicine, specifically focusing on cardiology and diagnostic tools. It adheres to the established norms of clinical research, including hypothesis testing, statistical analysis, and comparison against existing gold standards. Highlights The research presented in this preprint contributes to normal science

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Biobank-scale exposome-wide risk factors in CAD and T2D: observational, predictive, and potentially causative evidence

Leave a Comment / medRxiv, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2024.10.26.24316153v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of biomedicine and epidemiology, which emphasizes the interplay of genetic and environmental factors in disease development. It adheres to established research methodologies and statistical analyses commonly accepted in these fields. Highlights The study uses well-established methods like ExWAS and Mendelian Randomization,

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Deviation Error: assessing machine learning predictions for replicate measurements in genomics and beyond

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.29.656931v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the paradigm of machine learning applied to genomics, specifically focusing on predictive modeling for replicate measurements. It accepts the established methods and assumptions of this field, such as the use of standard loss functions and the focus on minimizing prediction error. Highlights This preprint

Deviation Error: assessing machine learning predictions for replicate measurements in genomics and beyond Read More »