Model Drift

Preprints revealing inconsistencies, weak fits, or unexplained anomalies in dominant models—early signs of conceptual stress within the current framework.

Constraints on maximum neutron star mass from proto-neutron star evolution

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6757777/v1_covered_31f5efe7-da24-4f9b-8d0b-4fac1e3d3fcc.pdf?c=1748452055 Stage Model Drift Paradigm framing The current paradigm for neutron stars is that they are composed primarily of neutrons, with some protons and leptons. There are a number of variations to this paradigm, including the presence of hyperons, kaons, or deconfined quarks. Highlights This preprint explores the impact of hyperons on the equation […]

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Reappraisal of the place of cultivated plants in the carbon budget

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.17.654640v1.full.pdf Stage Model Drift Paradigm framing Carbon Budget and Climate Change Highlights The preprint "Reappraisal of the place of cultivated plants in the carbon budget" challenges the current paradigm of carbon budget accounting within the broader climate change discourse. The established paradigm largely neglects the carbon capture and storage contribution of annual crops, focusing

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Non-enzymatic isothermal strand displacement and amplification (NISDA) does not enable sensitive nucleic acid quantification

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654176v1.full.pdf Stage Model Drift Paradigm framing Nucleic acid quantification using enzyme-free isothermal amplification methods Highlights This preprint presents an attempt to replicate and validate the non-enzymatic isothermal strand displacement and amplification (NISDA) assay, a recently introduced method for nucleic acid detection. The authors’ inability to reproduce the sensitivity levels reported in the original NISDA

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Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5675275/v1/bdabe3e5-a9fc-4672-8f25-56cea5d59024.pdf?c=1735751343 Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of ophthalmology, specifically glaucoma management. It seeks to refine existing treatment strategies for acute angle-closure glaucoma (AACG). Highlights This research investigates the application of high-intensity focused ultrasound cycloplasty (UCP) for AACG, a relatively novel technique within the existing

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Re-analyzed APOL1 kidney data support new ethics of ‘race’

Leave a Comment / medRxiv, Model Drift /

URL https://www.medrxiv.org/content/10.1101/2024.09.15.24313684v6.full.pdf Stage Model Drift Paradigm framing The dominant paradigm in nephrology research attributes disparities in kidney disease outcomes, particularly between Black and White patients, to genetic factors, notably variants of the APOL1 gene. This paradigm frames 'race' as a biologically meaningful category with direct causal links to health outcomes. Highlights This preprint challenges the

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Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.05.07.25327193v1.full.pdf Stage Normal Science / Model Drift Paradigm framing The current paradigm emphasizes that early revascularization is crucial for acute myocardial infarction (AMI) with cardiogenic shock, with both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) recognized as life-saving options. However, the choice between multi-vessel PCI and CABG in the specific setting

Mortality is substantially lower in patients undergoing coronary bypass grafting vs percutaneous coronary intervention with three-vessel coronary disease and cardiogenic shock in the setting of non-ST-elevation myocardial infarction Read More »

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation.

Leave a Comment / bioRxiv, Model Drift, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2025.05.16.654079v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of bioelectromagnetism, specifically focusing on the use of electric fields for neuromodulation. It uses established methodologies of computational bioelectromagnetism to analyze and model electric fields interaction with neural tissue. Highlights The preprint primarily contributes to "normal science" by

Closed-form expressions for the directions of maximum modulation depth in temporal interference electrical brain stimulation. Read More »

Judged by your neighbors: Brain structural normativity profiles for large and heterogeneous samples

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2024.12.24.24319598v2.full.pdf Stage Normal Science / Model Drift Paradigm framing The preprint operates within the paradigm of normative modeling in neuroimaging, which seeks to understand brain structure and function relative to established norms. Highlights This preprint presents a refinement (N³) of existing normative modeling techniques, aiming to address limitations in handling heterogeneity within study populations.

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Fuzzy Recurrence Dynamics of Contrast Medium Extravasation in Computed Tomography

Leave a Comment / medRxiv, Model Drift, Normal Science /

URL https://www.medrxiv.org/content/10.1101/2025.03.10.25323651v1.full.pdf Stage Normal Science / Model Drift Paradigm framing Established paradigm of computed tomography (CT) imaging analysis in trauma care. Highlights This preprint resides primarily within the normal science stage of Kuhn’s paradigm cycle. It operates within the established paradigm of CT imaging for trauma assessment but introduces a novel analytical approach (fuzzy recurrence

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Stimulant medications affect arousal and reward, not attention

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654915v2.full.pdf Stage Model Drift Paradigm framing The dominant paradigm is the attention-network model of stimulant action. This model suggests that stimulants primarily improve attention by directly modulating attention networks in the brain. Highlights This preprint challenges the prevailing paradigm by presenting evidence suggesting that the primary effect of stimulants is on arousal and reward

Stimulant medications affect arousal and reward, not attention Read More »