Research Square

Cracking the Undruggable: Discovery of a Mutation-Induced Cryptic Pocket in TP53 C238Y for Precision Oncology

Leave a Comment / Model Revolution, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6651642/v1/564bb168-231f-48c3-8fd7-d3cbf5797c65.pdf Stage Model Revolution Paradigm framing The established paradigm of mutant TP53 being "undruggable" due to a lack of stable binding pockets. Highlights This preprint presents compelling computational evidence challenging the current paradigm by demonstrating the existence of a mutation-induced cryptic pocket in the TP53 C238Y mutant. While the in silico findings are robust […]

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. Highlights The preprint investigates the effects of computational thinking (CT) training on executive functions in fifth-grade children. It falls under normal science because it operates within the established paradigms of cognitive science, educational science, and computer science. The study seeks to

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The QETRA Protocol: Pioneering Quantum Eavesdropping Detection with Classical SVM

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6786392/v1_covered_8851b04d-a5b5-4bfb-a3a9-b8900a9d2e18.pdf?c=1748865121.pdf Stage Normal Science / Model Drift Paradigm framing Quantum cryptography, specifically Quantum Key Distribution (QKD), currently operates under the paradigm of detecting eavesdropping through quantum bit error rate (QBER) analysis, as exemplified by the BB84 protocol. Highlights This preprint presents the QETRA protocol, which introduces a novel approach to eavesdropping detection within the

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Green Synthesis of Cuo Nanoparticles Using Gloriosa Superba L. Extract by Phytochemical Analysis and Antimicrobial Applications

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6764786/v1/2dc5cde3-f6c7-4b77-b079-dcfd5e9b9fd2.pdf?c=1748866802.pdf Stage Normal Science Paradigm framing Nanotechnology, Green Chemistry, Material Science, Microbiology. Highlights The preprint investigates the green synthesis of CuO nanoparticles using Gloriosa superba L. extract. This research falls under the normal science stage because it operates within the established paradigm of nanotechnology and green chemistry. It explores a specific application of existing

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf?c=1736735506 Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. The dominant paradigm is the cognitive development framework, specifically focused on executive functions, intertwined with the emerging paradigm of computational thinking in educational settings. Highlights This research firmly sits within the normal science stage. It operates under the established paradigm of

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Constraints on maximum neutron star mass from proto-neutron star evolution

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6757777/v1_covered_31f5efe7-da24-4f9b-8d0b-4fac1e3d3fcc.pdf?c=1748452055 Stage Model Drift Paradigm framing The current paradigm for neutron stars is that they are composed primarily of neutrons, with some protons and leptons. There are a number of variations to this paradigm, including the presence of hyperons, kaons, or deconfined quarks. Highlights This preprint explores the impact of hyperons on the equation

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Evidence for complex fixed points in pandemic data

Leave a Comment / Model Revolution, Paradigm Shift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-70238/v1_covered.pdf?c=1631840663 Stage Model Revolution / Paradigm Change Paradigm framing The preprint attempts to revolutionize the existing paradigm of epidemiological modeling, by introducing complex fixed points into the Renormalization Group (RG) framework. It challenges the conventional compartmental models and complex network diffusion techniques, which primarily focus on initial growth, by proposing a unified way to

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Preliminary study on the treatment of acute angle- closure glaucoma with high-intensity focused ultrasound cycloplasty

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5675275/v1/bdabe3e5-a9fc-4672-8f25-56cea5d59024.pdf?c=1735751343 Stage Normal Science / Model Drift Paradigm framing The preprint operates within the dominant paradigm of ophthalmology, specifically glaucoma management. It seeks to refine existing treatment strategies for acute angle-closure glaucoma (AACG). Highlights This research investigates the application of high-intensity focused ultrasound cycloplasty (UCP) for AACG, a relatively novel technique within the existing

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