bioRxiv

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions

Leave a Comment / bioRxiv, Normal Science /

URL https://www.biorxiv.org/content/10.1101/2024.06.28.601145v2.full.pdf Stage Normal Science Paradigm framing Current neurovascular coupling (NVC) and brain imaging paradigms Highlights The study uses established NVC concepts and advanced imaging techniques to investigate the role of astrocytes in NVC within the existing paradigm. There is no significant challenge to current paradigms but the study may inspire further studies. The research […]

Fast 3D imaging in the auditory cortex of awake mice reveals that astrocytes control neurovascular coupling responses at arteriole-capillary junctions Read More »

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill

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URL https://www.biorxiv.org/content/10.1101/2025.05.15.654070v1.full.pdf Stage Normal Science Paradigm framing The paradigm is the current understanding of oxygen sensing in vertebrates, which involves specialized respiratory chemoreceptors. This paradigm includes the established role of acetylcholine (ACh) in oxygen sensing in the mammalian carotid body and pulmonary neuroepithelial bodies (NEBs), as well as the recognized presence and role of serotonin

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Stimulant medications affect arousal and reward, not attention

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2025.05.19.654915v2.full.pdf Stage Model Drift Paradigm framing The dominant paradigm is the attention-network model of stimulant action. This model suggests that stimulants primarily improve attention by directly modulating attention networks in the brain. Highlights This preprint challenges the prevailing paradigm by presenting evidence suggesting that the primary effect of stimulants is on arousal and reward

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Oncolytic Maraba virus MG1 mediates direct and natural killer cell-dependent lysis of Ewing sarcoma

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URL https://www.biorxiv.org/content/10.1101/2025.05.16.654440v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the established use of chemotherapy, radiotherapy, and surgery for Ewing sarcoma. Highlights This preprint presents research on oncolytic Maraba virus MG1 as a potential treatment for Ewing sarcoma. The research is conducted within the framework of existing cancer treatment paradigms, exploring a new therapeutic

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Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body

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URL https://www.biorxiv.org/content/10.1101/2025.05.15.654311v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and proteomics, specifically focusing on the identification and quantification of proteins in blood as a means to understand physiological and pathological states. Highlights This research represents a significant contribution to normal science within the field of blood proteomics.

Deep Blood Proteomics Identifies over 12,000 Proteins Providing Valuable Information about the State of the Human Body Read More »