bioRxiv

Preprinting the COVID-19 pandemic

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URL https://www.biorxiv.org/content/10.1101/2020.05.22.111294v3.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of scientific communication, which traditionally involves peer-reviewed journal publications. However, it acknowledges a shift towards preprints, particularly in the context of the COVID-19 pandemic. Highlights This preprint examines the role of preprints in disseminating COVID-19 research. It analyzes preprints on bioRxiv […]

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Species synonyms depict changing but taxon-independent taxonomic praxis

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URL https://www.biorxiv.org/content/10.1101/2025.04.28.651127v2.full.pdf Stage Normal Science Paradigm framing Evolutionary biology, taxonomy, and marine biology. Highlights This preprint analyzes the synonymization of marine species names over time. It operates within the widely accepted paradigms of evolutionary biology and taxonomy, specifically focusing on how species are defined and how our understanding of their diversity changes with time. The

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Causal Lesion Evidence for Two Motor Speech Coordination Networks in the Brain

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URL https://www.biorxiv.org/content/10.1101/2025.06.05.658124v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of cognitive neuroscience, specifically focusing on the neural substrates of speech production. It adheres to the established methodologies of fMRI, lesion-symptom mapping, and anatomical tracing. The theoretical framework it investigates, the dual motor speech coordination model, is itself an extension of

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Two de novo transcriptome assemblies and functional annotations from juvenile cuttlefish (Sepia officinalis) under various metal and pCO2 exposure conditions

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URL https://www.biorxiv.org/content/10.1101/2025.06.03.657592v1.full.pdf Stage Normal Science Paradigm framing The paradigm framing of this research is genomics and molecular biology applied to ecotoxicology and environmental studies. Highlights This preprint presents two de novo transcriptome assemblies for the cuttlefish *Sepia officinalis*. This work fits within the "normal science" stage of Kuhn's paradigm cycle. The researchers are working within

Two de novo transcriptome assemblies and functional annotations from juvenile cuttlefish (Sepia officinalis) under various metal and pCO2 exposure conditions Read More »

Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

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URL https://www.biorxiv.org/content/10.1101/2024.06.13.598818v3.full.pdf Stage Normal Science Paradigm framing Cell Biology, Developmental Biology, Mitochondrial Inheritance, Chromosome Segregation Highlights This preprint investigates the role of Dynamin-related protein 1 (Drp1) in mitochondrial redistribution and partitioning during embryonic cleavage in mouse zygotes. The study uses established experimental techniques like Trim-Away, live imaging, and immunofluorescence to demonstrate that Drp1-mediated mitochondrial fragmentation

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Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam.

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URL https://www.biorxiv.org/content/10.1101/2025.06.03.657600v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular biology and genetics as applied to understanding and treating Spinal Muscular Atrophy (SMA). This paradigm emphasizes the role of SMN protein deficiency as the central cause of SMA and focuses on therapies that increase SMN levels. Highlights This preprint

Translation-specific disruption of Col1a1 expression in multiple models of Spinal Muscular Atrophy can be rescued by Risdiplam. Read More »

Behavioral plasticity and the valence of indirect interactions

Leave a Comment / bioRxiv, Model Drift /

URL https://www.biorxiv.org/content/10.1101/2024.08.15.608151v2.full.pdf Stage Model Drift Paradigm framing The preprint operates within the paradigm of predator-prey interactions and community ecology, specifically focusing on how individual behavior can influence population dynamics and species interactions. Highlights This preprint presents a model refinement of apparent competition by incorporating behavioral plasticity, specifically hiding behavior in prey species. The core paradigm

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Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK

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URL https://www.biorxiv.org/content/10.1101/2025.05.30.656906v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of molecular genetics and genomics, specifically focusing on the established understanding of gene mutations, RNA processing, and protein synthesis. It also adheres to the broader paradigm of Mendelian inheritance in explaining disease etiology. Highlights This preprint investigates the functional impact of

Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK Read More »

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin

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URL https://www.biorxiv.org/content/10.1101/2025.05.26.655791v1.full.pdf Stage Normal Science Paradigm framing The monoaminergic hypothesis of depression Highlights This research preprint investigates the effects of different antidepressant treatments on brain activity in mice, using c-fos expression as a marker. The study builds upon the established monoaminergic hypothesis of depression and aims to further elucidate the specific brain circuitry involved in

Converging pathways: shared brain circuitry engaged by monoaminergic antidepressants, ketamine and psilocybin Read More »

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration

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URL https://www.biorxiv.org/content/10.1101/2025.05.27.656424v1.full.pdf Stage Normal Science Paradigm framing The paradigm in this research preprint about heart regeneration centers around the translation initiation factors and their impact on regenerative processes. Specifically, the role of eif4e1c, a cap-binding protein unique to fish, is investigated in relation to its canonical counterparts eif4ea and eif4eb. Highlights This preprint falls under

Genes for 5’mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration Read More »