The Role of Blood-Brain Barrier Dysfunction in Mediating Autoantibody and Immune Cell Entry in Pediatric Anti-NMDA Receptor Encephalitis: A Comparative Study

The preprint operates within the dominant paradigm of neuroimmunology, specifically focusing on the role of blood-brain barrier dysfunction in pediatric anti-NMDA receptor encephalitis. This paradigm accepts the well-established understanding of the immune system's role in neurological disorders and the importance of the blood-brain barrier in maintaining CNS homeostasis.

This systematic review summarizes existing literature on the mechanisms and implications of blood-brain barrier dysfunction in pediatric anti-NMDA receptor encephalitis. It does not challenge the current paradigm or propose alternative theoretical frameworks. The study aims to refine existing knowledge within the established paradigm by comparing pediatric and adult cases and highlighting the developmental and immunological factors that contribute to the disease's pathophysiology in children. The research focuses on improving understanding within the accepted paradigm, rather than proposing a paradigm shift or revolution. Therefore, the study fits comfortably within the category of "Normal Science" as defined by Kuhn.