Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

The paper operates within the dominant paradigm of molecular biology, specifically focusing on the detailed mechanics of protein synthesis within the established framework of ribosomal function and the role of elongation factors.

This preprint investigates a specific mechanism within the established paradigm of ribosomal protein synthesis. It focuses on the role of L12 stalks in optimizing the delivery of elongation factors to the ribosome, thereby enhancing the efficiency of the translation process. The research uses computational modeling to explore this detailed mechanism, operating within the accepted theoretical framework and experimental findings of the field. This work does not challenge the existing paradigm but rather refines the understanding of a specific aspect within it. Thus, it is classified as Normal Science. While the use of computational modeling to investigate molecular details could be considered novel in the context of Kuhn's work (given that computational modeling did not exist when Kuhn originally wrote *The Structure of Scientific Revolutions*), it does not constitute a paradigm shift or model revolution. The model is built upon established knowledge and seeks to further validate and refine existing understandings of the translation process. Therefore, Normal Science is the most accurate classification for this preprint.