Factor H related 2 levels dictate FHR dimer composition

The preprint operates within the established paradigm of complement biology, specifically focusing on the role of Factor H and Factor H-Related proteins in regulating the alternative pathway of complement activation.

This preprint focuses on refining the understanding of the dynamic interactions and dimerization of FHR proteins, particularly FHR-2. It provides a novel method for quantifying FHR-2 homodimers and investigates the influence of genetic variations on FHR dimer distribution. While the research contributes valuable data and refines existing models, it does not challenge the fundamental understanding of complement regulation or propose a radical shift in the field. Therefore, it is classified as normal science within the existing paradigm. The research solidifies existing knowledge by providing direct experimental evidence for the distribution equilibrium of FHR dimers, previously based on theoretical calculations. It also contributes to a more precise understanding of the effects of genetic variations in CFHR2 on FHR levels and dimerization. These findings deepen the understanding within the current paradigm without fundamentally altering its core principles.