Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases

The preprint operates within the dominant paradigm of genetic epidemiology, specifically focusing on the interplay of genes and environment in complex diseases. It adheres to the established methodologies of Genome-Wide Association Studies (GWAS) and related statistical analyses.

This preprint investigates the genetic relationship between severe mental disorders and autoimmune diseases using established GWAS methodologies and advanced statistical analyses. It builds upon existing research within the field of genetic epidemiology, exploring shared genetic architectures and potential pleiotropic effects. The research doesn't challenge the existing paradigm but rather contributes to the growing body of knowledge within it, making incremental advancements in understanding the complex interplay of genetics and environment in these conditions. Therefore, it is classified as Normal Science. While the study identifies novel genetic loci and potential drug targets, these findings represent refinements within the current paradigm rather than a revolutionary shift.