Research Square

URL https://www.researchsquare.com/article/rs-7776000/v1.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of competitive lateral flow immunoassay (LFIA) as a tool for rapid, qualitative chemical detection. This study applies the accepted principles of LFIA to the specific public health and harm reduction problem of drug checking. It focuses on comparing and refining existing […]

URL https://www.researchsquare.com/article/rs-7832668/v1.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of sensory psychology and cognitive neuroscience, which posits that visual cues are critical modulators of appetitive behavior. Specifically, it builds on the model that color saturation acts as a primary signal for food reward value, influencing hedonic ("liking") and motivational ("wanting")

URL https://www.researchsquare.com/article/rs-7723812/v1.pdf Stage Normal Science Paradigm framing This research is situated within the established paradigm of behavioral neuroscience that investigates the neurobiological underpinnings of addiction. Specifically, it operates within the incentive-salience theory of addiction, which posits that the mesolimbic dopamine system mediates the attribution of motivational value to reward-associated cues. The study uses the Pavlovian

URL https://assets-eu.researchsquare.com/files/rs-7603035/v1/da778077-560b-4fee-87f3-582327e9d2bb.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of behavioral neuroscience, which posits that stress-related disorders like PTSD arise from maladaptive fear learning governed by specific neural circuits (e.g., amygdala) and neurochemical systems (e.g., glutamatergic NMDA receptors). This paradigm uses animal models and standardized behavioral tests, such as fear

URL https://assets-eu.researchsquare.com/files/rs-7743842/v1_covered_ba817f41-f387-49eb-8aa7-1690983cce78.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of regional climate science, which uses numerical Regional Climate Models (RCMs) coupled with Land Surface Models (LSMs) to simulate and project climate dynamics. Specifically, it uses the RegCM-CLM framework. A common practice, or sub-paradigm, within this field has been the use

URL https://assets-eu.researchsquare.com/files/rs-7820101/v1/0ee422b2-46ea-402a-a33f-52d9c4ac480e.pdf Stage Normal Science Paradigm framing The paper operates within the established paradigm of geographic information science (GIS) for modeling spatial accessibility. This paradigm relies on cost-distance analysis, which uses geospatial data like land cover, elevation, and transport networks to calculate travel time to services. The AccessMod tool itself is a key instrument within

URL https://assets-eu.researchsquare.com/files/rs-7857283/v1/7790ccc6-4e08-4241-a06a-3a846cbf71f5.pdf Stage Normal Science Paradigm framing This research operates within the established paradigm of evidence-based psychological interventions, specifically Compassion-Based Interventions (CBIs). It accepts the core tenets that compassion is a trainable skill and that its effects can be measured through self-report and physiological markers. The study introduces a technological tool, Virtual Reality (VR), not

URL https://assets-eu.researchsquare.com/files/rs-7700502/v1/1c2c1f3d-5ce6-4d13-ae61-af459d0ff005.pdf Stage Normal Science Paradigm framing The research is situated within the surgical urology paradigm for treating ureteral strictures. This paradigm accepts that anatomical defects like strictures can be repaired through reconstruction, often using autologous tissue grafts. The core scientific puzzles involve optimizing surgical techniques (e.g., Onlay vs. Tubularized reconstruction) and selecting the best

URL https://assets-eu.researchsquare.com/files/rs-7841195/v1/037745ac-e5aa-4a96-907f-95d1b958db4b.pdf Stage Normal Science Paradigm framing The research operates within the established paradigm of precision medicine, specifically using antisense oligonucleotide (ASO) technology to treat monogenic neurological disorders. It further relies on the paradigm of using whole-genome sequencing to identify patient-specific genetic variants that enable highly targeted therapeutic design. The study aims to solve the

URL https://www.researchsquare.com/article/rs-6875121/v1.pdf Stage Normal Science Paradigm framing This research operates firmly within the established paradigms of conservation biology and climate change ecology. It utilizes ecological niche modeling (ENM) as a standard tool to predict species distributions under future climate scenarios, a widely accepted methodology in the field. The study is framed by the prevailing understanding