Research Square

3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes

Leave a Comment / Normal Science, Research Square /

URL https://www.researchsquare.com/article/rs-6759572/v1.pdf Stage Normal Science Paradigm framing The current paradigm in Type 1 diabetes (T1D) research centers around the autoimmune destruction of insulin-producing β-cells in the pancreas. This preprint works within this established paradigm. Highlights This research utilizes advanced 3D imaging techniques (light sheet fluorescent microscopy) to investigate the size, composition, and distribution of pancreatic […]

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Trajectory of thirst level in critically ill oncology patients: A group-based trajectory model

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6488220/v1_covered_bf14d4c6-0551-46a0-bc69-380fce1a703d.pdf Stage Normal Science Paradigm framing The paradigm framing is thirst assessment and management in critically ill patients, particularly those in oncology. The dominant paradigm accepts the importance of thirst management and investigates its prevalence, intensity, and related factors in the ICU setting. This study operates within this paradigm by investigating thirst level trajectories

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Exploring the use of Virtual Reality to enhance rapid decompression from occupational stress during short wellness breaks for content moderators

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5684444/v1_covered_6871fded-8bc3-44c1-a101-5f10e11abdc8.pdf Stage Normal Science Paradigm framing Psychology, Occupational Health, Human-Computer Interaction Highlights This preprint investigates the application of Virtual Reality (VR) for stress reduction in a specific occupational group (content moderators). While the study did not demonstrate significant changes in long-term, trait-based anxiety or occupational stress, it did show reductions in short-term, state-based stress

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Cracking the Undruggable: Discovery of a Mutation-Induced Cryptic Pocket in TP53 C238Y for Precision Oncology

Leave a Comment / Model Revolution, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6651642/v1/564bb168-231f-48c3-8fd7-d3cbf5797c65.pdf Stage Model Revolution Paradigm framing The established paradigm of mutant TP53 being "undruggable" due to a lack of stable binding pockets. Highlights This preprint presents compelling computational evidence challenging the current paradigm by demonstrating the existence of a mutation-induced cryptic pocket in the TP53 C238Y mutant. While the in silico findings are robust

Cracking the Undruggable: Discovery of a Mutation-Induced Cryptic Pocket in TP53 C238Y for Precision Oncology Read More »

Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. Highlights The preprint investigates the effects of computational thinking (CT) training on executive functions in fifth-grade children. It falls under normal science because it operates within the established paradigms of cognitive science, educational science, and computer science. The study seeks to

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The QETRA Protocol: Pioneering Quantum Eavesdropping Detection with Classical SVM

Leave a Comment / Model Drift, Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6786392/v1_covered_8851b04d-a5b5-4bfb-a3a9-b8900a9d2e18.pdf?c=1748865121.pdf Stage Normal Science / Model Drift Paradigm framing Quantum cryptography, specifically Quantum Key Distribution (QKD), currently operates under the paradigm of detecting eavesdropping through quantum bit error rate (QBER) analysis, as exemplified by the BB84 protocol. Highlights This preprint presents the QETRA protocol, which introduces a novel approach to eavesdropping detection within the

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Green Synthesis of Cuo Nanoparticles Using Gloriosa Superba L. Extract by Phytochemical Analysis and Antimicrobial Applications

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URL https://assets-eu.researchsquare.com/files/rs-6764786/v1/2dc5cde3-f6c7-4b77-b079-dcfd5e9b9fd2.pdf?c=1748866802.pdf Stage Normal Science Paradigm framing Nanotechnology, Green Chemistry, Material Science, Microbiology. Highlights The preprint investigates the green synthesis of CuO nanoparticles using Gloriosa superba L. extract. This research falls under the normal science stage because it operates within the established paradigm of nanotechnology and green chemistry. It explores a specific application of existing

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Computational Thinking Training and Its Effects on Working Memory, Flexibility, and Inhibition: Controlled Trial in Fifth-Grade Children

Leave a Comment / Normal Science, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-5707155/v1/71d31c12-0fd1-46be-86c3-8e6df78f8f1e.pdf?c=1736735506 Stage Normal Science Paradigm framing Cognitive Science, Educational Science, and Computer Science. The dominant paradigm is the cognitive development framework, specifically focused on executive functions, intertwined with the emerging paradigm of computational thinking in educational settings. Highlights This research firmly sits within the normal science stage. It operates under the established paradigm of

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Constraints on maximum neutron star mass from proto-neutron star evolution

Leave a Comment / Model Drift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-6757777/v1_covered_31f5efe7-da24-4f9b-8d0b-4fac1e3d3fcc.pdf?c=1748452055 Stage Model Drift Paradigm framing The current paradigm for neutron stars is that they are composed primarily of neutrons, with some protons and leptons. There are a number of variations to this paradigm, including the presence of hyperons, kaons, or deconfined quarks. Highlights This preprint explores the impact of hyperons on the equation

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Evidence for complex fixed points in pandemic data

Leave a Comment / Model Revolution, Paradigm Shift, Research Square /

URL https://assets-eu.researchsquare.com/files/rs-70238/v1_covered.pdf?c=1631840663 Stage Model Revolution / Paradigm Change Paradigm framing The preprint attempts to revolutionize the existing paradigm of epidemiological modeling, by introducing complex fixed points into the Renormalization Group (RG) framework. It challenges the conventional compartmental models and complex network diffusion techniques, which primarily focus on initial growth, by proposing a unified way to

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