ChemRxiv - Preprint Watch

Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore

URL https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/64660c73f2112b41e9c0f70d/original/cobalt-bis-dicarbollide-is-a-dna-neutral-pharmacophore.pdf Stage Normal Science Paradigm framing The paradigm framing of this research preprint is the well-established understanding of DNA interactions with small molecules, particularly those used as therapeutic agents. This includes the accepted mechanisms of DNA binding, such as intercalation, groove binding, and electrostatic interactions, and the typical structural characteristics of molecules that engage […]

Cyanobacteria Join the Kahalalide Conversation: Genome and Metabolite Evidence for Structurally Related Peptides

Leave a Comment / chemRxiv, Normal Science / Preprint Watch

URL https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/683e27bf1a8f9bdab54cfe62/original/cyanobacteria-join-the-kahalalide-conversation-genome-and-metabolite-evidence-for-structurally-related-peptides.pdf Stage Normal Science Paradigm framing Natural Products Chemistry, Genomics, and Bioinformatics Highlights This preprint focuses on the discovery and characterization of kahalalide Z5 (KZ5), a cyclic depsipeptide with structural similarities to the known anticancer compound kahalalide F. The research uses established techniques like NMR, MS, and chemical degradation, combined with AI-driven tools (SMART

Cyanobacteria Join the Kahalalide Conversation: Genome and Metabolite Evidence for Structurally Related Peptides Read More »