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Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI

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URL https://www.biorxiv.org/content/10.1101/2025.05.16.654552v2.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of using functional magnetic resonance imaging (fMRI) and network neuroscience to study brain function and disorders. Specifically, it focuses on the sub-paradigm of dynamic functional connectivity (DFC) analysis, which has gained traction in recent years as a way to capture the […]

Change point based dynamic functional connectivity estimation outperforms sliding window and static estimation for classification of early mild cognitive impairment in resting-state fMRI Read More »

Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans

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URL https://www.biorxiv.org/content/10.1101/2025.03.21.644675v2.full.pdf Stage Normal Science Paradigm framing The current paradigm is the understanding of the phenotypic effects of ribosomal DNA (rDNA) copy number variation in model organisms. Highlights This preprint investigates the phenotypic consequences of natural rDNA copy number variation in *C. elegans*, a topic within the current paradigm of understanding the phenotypic effects of

Phenotypic tolerance for rDNA copy number variation within the natural range of C. elegans Read More »

IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells

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URL Stage https://www.biorxiv.org/content/10.1101/2025.05.09.652839v2 Normal Science Paradigm framing The preprint operates within the established paradigm of T cell-mediated immunity, specifically focusing on the role of IFNγ in cytotoxic CD8+ T cell function. This paradigm encompasses the understanding that CD8+ T cells recognize and eliminate infected or cancerous cells, and that cytokines like IFNγ play crucial roles

IFNγ expression correlates with enhanced cytotoxicity in CD8+ T cells Read More »

Molecular Basis of Sodium Channel Inactivation

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URL https://www.biorxiv.org/content/10.1101/2025.05.22.655422v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the established paradigm of voltage-gated sodium channel function and inactivation, specifically focusing on the molecular mechanisms underlying fast inactivation. Highlights This research utilizes established experimental techniques like site-directed mutagenesis, voltage clamp fluorimetry, and electrophysiology to investigate a specific aspect of sodium channel inactivation. The

Molecular Basis of Sodium Channel Inactivation Read More »

Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli

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URL https://www.biorxiv.org/content/10.1101/2023.04.14.536948v3.full.pdf Stage Normal Science Paradigm framing The paper operates within the dominant paradigm of molecular biology, specifically focusing on the detailed mechanics of protein synthesis within the established framework of ribosomal function and the role of elongation factors. Highlights This preprint investigates a specific mechanism within the established paradigm of ribosomal protein synthesis. It

Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli Read More »

CombiCTx: Screening diffusion gradients of anti-cancer drug combinations

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URL https://www.biorxiv.org/content/10.1101/2025.02.27.635465v1.full.pdf Stage Normal Science Paradigm framing The preprint operates within the dominant paradigm of in vitro cancer drug screening, specifically focusing on combination therapies. It adheres to the established methodology of evaluating drug efficacy and interactions, employing well-established techniques like microscopy and cell viability assays. Highlights This preprint presents a refinement of existing drug

CombiCTx: Screening diffusion gradients of anti-cancer drug combinations Read More »

A male-transmitted B chromosome undergoes strong meiotic drag in females

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URL https://www.biorxiv.org/content/10.1101/2025.05.20.655026v1.full.pdf Stage Normal Science Paradigm framing The paper operates within the paradigm of Mendelian inheritance and chromosome theory, but focuses on an exception to the standard model: the non-Mendelian inheritance of B chromosomes. Highlights This research falls under normal science because it investigates a specific phenomenon (the inheritance of the PSR B chromosome) within

A male-transmitted B chromosome undergoes strong meiotic drag in females Read More »

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

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URL https://www.biorxiv.org/content/10.1101/2025.05.21.654986v1.full.pdf Stage Normal Science Paradigm framing The current paradigm for treating genetic spermatogenic disorders includes hormone therapy and microdissection testicular sperm extraction (micro-TESE), which offer limited success. Gene therapies, specifically using CRISPR/Cas9, have shown promise in preclinical models but face challenges regarding off-target risks, ethical concerns, and limited clinical translatability. Highlights This preprint falls

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders Read More »

Navigating contradictions: Salmonella Typhimurium chemotaxis amidst conflicting stimuli of the intestinal environment

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URL https://www.biorxiv.org/content/10.1101/2024.01.18.576330v4.full.pdf Stage Normal Science Paradigm framing Chemotaxis Highlights The preprint investigates the role of chemotaxis in *Salmonella Typhimurium* within the complex chemical environment of the gut, specifically focusing on the interaction between indole and other chemoeffectors. This research falls under normal science as it operates within the established paradigm of chemotaxis, seeking to refine

Navigating contradictions: Salmonella Typhimurium chemotaxis amidst conflicting stimuli of the intestinal environment Read More »