A Transient Increase in Cardiomyocyte Protein O-GlcNAcylation Enhances Susceptibility to Pressure Overload-Induced Cardiac Remodeling

The preprint operates within the dominant paradigm of metabolic memory in diabetic heart disease, specifically focusing on the role of O-GlcNAcylation.

This research uses established models and methodologies to investigate a specific aspect of metabolic memory within the existing paradigm. The study builds upon prior knowledge and refines the understanding of O-GlcNAc's role in this process, which aligns with the characteristics of Kuhn's Normal Science. While the study proposes "O-GlcNAc memory," it is presented as a component within the broader context of metabolic memory, not a revolutionary new paradigm. The research seeks to expand knowledge within the current framework rather than challenge or replace it. Therefore, the classification is Normal Science.