Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas

The current paradigm encompasses allograft dysfunction as an organ-specific process with varying molecular responses depending on the transplanted organ.

This preprint operates within the existing paradigm of allograft dysfunction, but pushes the boundaries by exploring the concept of "pan-organ allograft dysfunction." It introduces the novel idea that pathophysiological genomic signatures are agnostic of organ type. While this challenges the established paradigm of organ-specific responses, the research primarily focuses on refining and expanding current understanding by identifying shared molecular markers and developing a new analytical framework (TOP). Thus, it represents an advancement within normal science, potentially setting the stage for a model drift or even a crisis if the pan-organ concept gains further traction and challenges organ-specific treatment approaches. If the validation proves extremely robust with more diverse external datasets, the pan-organ model may challenge the organ-specific nature of the current paradigm, leading to a model revolution. Therefore, I have difficulty distinguishing between normal science and model drift. There currently aren't competing paradigms, as the field uses an organ-specific approach by default.