Epigenetic mediation may explain intergenerational associations between maternal lifestyle and birth weight of offsprings – Findings from the NorthPop prospective birth cohort

The preprint operates within the dominant paradigm of DOHaD (Developmental Origins of Health and Disease), specifically focusing on the role of epigenetics in mediating the relationship between maternal lifestyle during pregnancy and offspring birth weight. It utilizes established methodologies of statistical analysis and DNA methylation assessment, working within the accepted framework of epidemiological studies and molecular biology.

This research firmly falls under normal science. It investigates a specific problem (the epigenetic mechanisms linking maternal lifestyle and birth weight) within the established DOHaD paradigm. The study employs standard research techniques (regression analysis, DNA methylation profiling), seeks to refine existing knowledge, and doesn’t challenge the prevailing theoretical framework. There’s no evidence of paradigm drift, crisis, or revolution. The study contributes to the cumulative progress of normal science by adding further evidence and detail to the existing body of knowledge within the DOHaD paradigm.