Genetic signatures of bipolar disorder course specifiers

The preprint operates within the dominant paradigm of psychiatric genetics, which emphasizes the role of genetic factors in the development and manifestation of mental disorders. It also adheres to the dimensional approach to psychopathology, viewing mental illness as existing on a spectrum rather than as discrete categories.

This preprint falls under the category of normal science due to its investigation of a specific phenomenon (genetic signatures of bipolar disorder course specifiers) within an established paradigm. It utilizes standard research methods like EFA, CFA, and SEM to analyze data and test hypotheses derived from the existing paradigm. While the study identifies a novel 'psychosocial functioning' dimension, this refinement of existing models doesn't challenge the fundamental assumptions of the field. It rather contributes to the cumulative knowledge within the current paradigm by exploring the genetic contributions to this newly identified dimension and its association with poorer outcomes. There is no evidence suggesting a model drift, crisis, revolution, or paradigm change. The preprint focuses on adding detail to the existing paradigm by expanding the understanding of the genetic factors related to BD course specifiers.